Vol 9, No 3 (2015)


Lornoxicam effect on emostasis in patients after craniotomy in early postoperative period

Imaev A.A., Dolmatova E.V., Solenkova A.V., Moshkin A.V., Kulikov A.S., Lubnin A.Y.


Lornoxicam, one of NSAIDs, is considered as effective medication for postoperative analgesia. One of the well-known side effects of NSAIDs is hypocoagulation which can be dangerous in neurosurgery. The goal of this study was assessment of lornoxicam influence on hemostasis in perioperative period. Materials and methods: 20 patients after craniotomy for tumor removal were enrolled in the study. Lornoxicam was used in “scheduled” dosing mode: 8 mg during anesthesia induction, followed by 8 mg each 8 hours for 3 days. TEG and PFA analysis were used for hemostasis assessment on 0,1,3 and 5 days of perioperative period. Results: We didn't detected hypocoagulation in patients during the study. Moreover we noted a tendency for hypercoagulation in early postoperative period. It can be explained by hemostasis activation by intraoperative trauma. This effect is seemed more significant than hypocoagulation effect of NSAID in our group of patients. Conclusion: “Scheduled” dosing of lornoxicam don't inhibit hemostasis in neurosurgical patients.
Regional Anesthesia and Acute Pain Management. 2015;9(3):5-13
pages 5-13 views

Evaluation of autonomic nervous system state in the patients with trauma of distal part of lower limb during perioperative period depending on type of anesthesia

Murashova N.A., Lyuboshevskij P.A., Larionov S.V., Ganert A.N.


Data about the early postoperative period at 90 patients operated on distal part of the lower extremities, depending on a type of anesthesia, there are submitted in the article. There were compared patients with the isolated spinal anesthesia, patients with spinal anesthesia in combination with local anesthesia of a zone of surgery and patients with a combination of spinal anesthesia and peripheral nerves blocks. It is proved that the most prefer option of anestesia is the combination of spinal anesthesia with blockade of nerves of the bottom extremity. This type of anesthesia allows not only to stop a pain syndrome effectively, but also to provide stable indicators of a neurovegetative homeostasis in the early postoperative period.
Regional Anesthesia and Acute Pain Management. 2015;9(3):14-18
pages 14-18 views

The analysis of effectiveness of isolated and combined prescription of non-opioid analgesics and adjutants during different surgery

Efremenko I.V., Ovechkin A.M., Krasnoselskiy M.Y.


The paper presents the results of clinical study conduced in order to compare the effectiveness of different non-opioid analgesics and adjuvants affecting the NMDA-receptors and applied for prophylaxis and management of acute postoperative pain. The study includes 347 patients undergone appendectomy, inguinal hernia repair, laparoscopic cholecystectomy. It was show that some non-opioid analgesics (NSAIDs) and adjuvans (ketamine, gabapentin) reduce pain intensity and opioid analgesics consumption for some surgical manipulations and are not effective for the other surgery. Complex prescription of NSAIDs, ketamine and gabapentin significantly reduces intensity of postoperative pain in all conditions and allows refusing from using of opioid analgesics.
Regional Anesthesia and Acute Pain Management. 2015;9(3):19-28
pages 19-28 views

Anesthesia in patients with cerebral palsy

Diordiev A.V., Ayzenberg V.L., Yakovleva E.S.


The article presents detailed discussion of somatic features of patients with cerebral palsy, tactics of anesthetic aid and postoperative analgesia. The authors determined indications and contraindications for balanced anesthesia, based on different regional block.
Regional Anesthesia and Acute Pain Management. 2015;9(3):29-36
pages 29-36 views

Selected chapters from the monograph "Regional Anesthesia in Pediatrics" Pharmacology and Pharmacokinetics of modern local anesthetics and adjuvants for regional analgesia in children

Ayzenberg V.L., Ulrikh G.E., Tsypin L.E., Zabolotskiy D.V.


The lecture discusses the question of pharmacodynamics and pharmacokinetics of local anesthetics and adjuvants applied for regional analgesia in pediatrics.
Regional Anesthesia and Acute Pain Management. 2015;9(3):37-44
pages 37-44 views

Systemic toxicity of local anesthetics in regional anesthesia

Koryachkin V.A., Geras’kov E.V., Kazarin V.S., Lis’kov M.A., Mokhanna M., Mal’tse M.P., Malevich G.M.


The article presents description of clinical case of lipid emulsion rescue during severe toxic reaction occurred in reply to accidental intravenous injection of local anesthetic solution. The article includes comprehensive data about epidemiology, clinical course and treatment of systemic toxicity of local anesthetics. It considers up-to-date understanding of mechanisms of antitoxic effect of lipid emulsion. The protocol of lipid emulsion rescue during systemic toxicity of local anesthetics is presented in the paper.
Regional Anesthesia and Acute Pain Management. 2015;9(3):45-50
pages 45-50 views

Anesthesia in pregnant women with obesity. Clinical guidelines (treatment protocols)

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The paper describes comprehensively physiological changes in pregnant women with obesity. It also presents deep analysis of up-to-date publications devoted to anesthesia and analgesia in obese pregnant women. All proposed treatment protocols and guidelines for anesthesia and perioperative analgesia in pregnant women with obesity are base on modern statistical and expert analytical methods.
Regional Anesthesia and Acute Pain Management. 2015;9(3):51-61
pages 51-61 views

Interpretation of study findings: Strategy and tactics of evidence base development

Tikhova G.P.


The paper proposes recommendations and algorithm for analizing clinical study results obtained in statistical processing of data in order to confirm statistical significance of the effect and detect possible bias and confounders.
Regional Anesthesia and Acute Pain Management. 2015;9(3):62-69
pages 62-69 views

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