Vol 101, No 3 (2022)

The role of water and aquaporin system in artificial lighting conditions and their importance for vision and the human body as a whole is considered.

The review used the databases Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, and RSCI. 

The functionally necessary level of water exchange in the human eye was shown to largely depend on the efficiency of aquaporins exposed to aggressive environment.  Such effects include an excessive dose of blue light, electromagnetic radiation, and excessive concentration of mercury, copper ions, and zinc ions in the human body. In the conditions of chemical pollution, excessive blue light, the violated efficiency of aquaporins leads to swelling in the functional structures of the eye, changes in their optical characteristics. So far the conditions for the development of diseases of the visual analyzer are created. The optical system of the eye is very sensitive to the geometric dimensions of the cornea, iris, lens and Muller cells. Edema of these cells is the primary causes of optical distortions of images on the retina. 

The positive effect of humoral regulators of aquaporin activity (vasopressin, estrogens, component of the renin-angiotensin system) on the lens transparency was shown. Aquaporin-0 plays a key role in the development of the refractive index gradient in the mammalian eye lens to prevent spherical aberration.

Aquaporin system permeates all cells of the functional structures of the body. A number of researchers suggest structural disorders of water dynamics between and within cells to be the basis of many diseases. More recent data have shown that aquaporin may also be associated with tumor, proliferation and migration of tumor cells, as well as angiogenesis in solid and hematological tumors. 

The discovery of aquaporins, which provide rapid transport of water through the biological membranes of all living organisms (animals, plants and microorganisms) has disproved the traditional concept and was an outstanding achievement of General biology, botany, physiology, medicine and ophthalmology. 

Changing the properties of intercellular water in artificial lighting (and other negative factors) is a new physiological and hygienic problem.

Contributions:

Kaptsov V.A. — the concept and design of the study, writing the text, design and editing of the article, responsibility for the integrity of all parts of the article.

Deynego V.N. — material collection, data processing, text writing.

Shipilov I.V. — material collection and data processing. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: November 12, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

Introduction. High morbidity rates of diseases of the endocrine system and the existing features of drinking water pollution with organochlorine compounds (OCCs) make it necessary to study the mechanisms of the influence of low doses of organochlorine pesticides on public health.

The purpose of the study is to study the features of the formation of non-carcinogenic risk in the population associated with exposure to OCCs in drinking water and endocrine disorders, using the example of 2,4-dichlorophenoxyacetic acid (2,4-D) under conditions of chronic oral exposure in small doses in the experiment.

Materials and methods. According to the results of a comparative hygienic assessment of more than 10 thousand samples of drinking water from centralized water supply in 41 municipalities of the Orenburg region, a rural area with the highest content of OCCs and 2,4-D was identified. There was executed an analysis of the incidence of diseases of the endocrine system, digestive system and metabolic disorders (E00-E90) in the population. The experimental part of the work was carried out on 2 groups of Wistar rats: the 1^st group was control, the 2^nd group consumed water containing 2,4-DA (ammonium salt of 2,4-dichlorophenoxyacetic acid) at a concentration of 0.015 mg/l (0.5 MPC). In the blood serum of animals, an analysis was made of the level of hormones: triiodothyronine (T3) and thyroid hormone (T4), testosterone and insulin, with an assessment of body weight and epididymal fat.

Results. The observation area was established to be characterized by a high level of contamination of drinking water with OCCs and mainly with 2,4-D. 

Non-carcinogenic risk for the endocrine system (0.005), corresponding to an acceptable level, is significantly higher by 2–4 times (p < 0.05) for adults and children than in the comparison area. The primary incidence of diseases of the endocrine system, digestive system and metabolic disorders (E00-E90) in the observation area (34.88±5.9) is by 2 times higher than the average regional value and 6 times in the comparison area, which indicates the manifestation of disruptive properties 2,4-D and OCCs. The experiment showed that in animals of the experimental group, body weight on day 135 is 10% higher than the control one. An increase in the level of insulin in animals of the experimental group by 70% on day 45 and by 25% on days 90 and 135 of the experiment was established. In the experimental group, on the 45^th, 90^th and 135^th days, the concentrations of T3 decreased by 22%, 5% and 6%, and T4 — by 13%, 12% and 38%, respectively. By the end of the experiment, the testosterone content in the experimental group was lower by 36%.

Limitations. The limitations of the study are related to the transfer of the results of experimental data to the studied exposed population and the assessment of only OCCs and 2,4-dichlorophenoxyacetic acid (2,4-D) in drinking water without taking into account other environmental factors.

Conclusion. The conducted study testifies to the manifestation of the disruptive properties of 2,4-D in an animal experiment, which is expressed by a violation of the mechanisms of metabolism regulation. The results of the experiment showed the intake of small doses (0.5 MPC) of 2,4-D into the body to have an obesogenic effect, manifested in a gain in total body weight and epididymal fat, accompanied by a decrease in the level of testosterone and thyroid hormones in the blood serum.

Contribution:

Kryazhev D.A. — the concept and design of the research, obtaining data for analysis, analyzing the data obtained, methodology, project management, resources, software, editing, writing the text of the manuscript, conceptualization, obtaining funding, supervision, check, visualization, review of publications on the topic of the article, editing of the material, approval of the final version of the article, responsibility for the integrity of all parts of the article;

Boev V.M. — the concept and design of the research, editing, approval of the final version of the article, responsibility for the integrity of all parts of the article;

Krasikov S.I. — the concept and design of the research, editing, approval of the final version of the article, responsibility for the integrity of all parts of the article;

Karmanova D.S. — obtaining data for analysis, analyzing the data obtained; methodology; project management; resources; software, writing the text of the manuscript, conceptualization, obtaining funding, supervision, check, visualization, review of publications on the topic of the article, editing of the material. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version;

Boeva T.V. — review of publications on the topic of the article, editing of the material. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: September 14, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

The article discusses a functional-ecological approach to the selection of soils for the purpose of hygienic regulation of chemicals. The functional-ecological approach used to substantiate the choice of soil types in standardization is associated with the analysis of their main, variable functional characteristics including humus state, particle size distribution, oxidizing capacity, sorption capacity, cation exchange capacity, etc. The choice of the type of soil can be made using the data on the classes, distinguished by the parameters of the stability of the functioning of the soils. The approach will allow making a rational choice of soils from all their diversity. According to the degree of stability and development, it is proposed to use contrasting options for soils, taking into account the area they occupy. The functional-ecological approach does not imply the choice of a specific soil characteristic, but takes into account the cumulative assessment of all soil properties according to the principle of their sustainability. In addition, it is advisable to create a network for hygienic rationing and maintain a database of the results obtained throughout the country. 

The main databases for the literature search were Scopus, Web of Science (WoS), Global Health, CyberLeninka, scientific electronic library elibrary.ru (RSCI). Since this topic affects the formation of an approach in the guidelines for determining the maximum permissible concentration, the review publication included information on National Russian standards, educational (national Atlas of soils of the Russian Federation, WRB — World Reference Base of Soil Resources) and scientific literature.

Contribution:

Voronina L.P. — research concept and design, collection and processing of material, writing a text and editing, approval of the final version of the article, responsibility for the integrity of all parts of the article;

Ponogaybo K.E. — collection and processing of material, writing a text and editing, approval of the final version of the article, responsibility for the integrity of all parts of the article;

Savostikova O.N. — research concept and design, editing, approval of the final version of the article, responsibility for the integrity of all parts of the article.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The research was carried out as part of a state assignment on the topic: “Risk assessment of the effects of anti-icing materials on human health and the environment when they are used in urban areas” at the Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency of the Russian Federation.

Received: October 20, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

Introduction. The purpose of the study is to assess the health status of the adult population of the Lermontov city, Stavropol Territory, living in the “uranium legacy” area in conditions of increased exposure to radon in residential premises has been investigated.

Materials and methods. The material of the study was the medical statistics data for the period 2009–2018 reported by Clinical Hospital No. 101 under FMBA of Russia, presented in forms No. 7 (information on malignant diseases) and No. 12 (information on the number of diseases in adults). The frequency, structure and dynamics of primary morbidity and incidence of malignant neoplasms were evaluated.

Results. During the period under review, a high primary incidence in the adult population was revealed (average: 748.2 ± 111.4 per 1000 persons) to increase and significantly exceeded the same indicator in the Stavropol Territory (390.3 ± 20.3 per 1000 persons) The incidence of four classes of diseases: diseases of the musculoskeletal system and connective tissue, diseases of the genitourinary system, diseases of the skin and subcutaneous tissue, diseases of the eye and adnexa was significantly higher than the regional average value. The incidence of respiratory diseases (lungs — a critical organ to the action of radon) did not significantly differ from the average regional indicators. On the contrary, the incidence of malignant neoplasms decreased (330.6 ± 1.1 per 100.0 persons) and on average approached that in the region (320.5 ± 11.4 per 100.0 persons). At the same time, the incidence of lung cancers was significantly lower than the regional average (22.6 ± 3.0 and 33.5 ± 0.3 per 100.0 persons, respectively).

Limitations. The study is limited to studying the state of incidence (primary, cancer) of Lermontov adult population. The estimation of the relative number of excess lung cancers is based on the expert assessment of the ICRP of the corresponding coefficient.

Conclusion. According to medical statistics for 2009–2018, the population of Lermontov had a relatively low incidence of malignant neoplasms, including lung cancers, of which, according to theoretical estimates, no more than 15–20% of cases can be conditionally associated with radon exposure. The revealed relatively high primary incidence of the adult population seems to be associated with the adverse impact on health of numerous factors of the human environment. Presumably, this situation also reflects the availability of quality medical care for the population.

Contribution:

Petoyan I.M. — the concept and design of the study, statistical processing, writing a text, responsible for the integrity of all parts of the manuscript;

Shandala N.K. — the concept and design of the study, text editing;

Titov A.V. — the concept and design of the study, writing a text;

Zinovieva N.V. — collection and processing of material.

All authors are responsible for approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: November 10, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

Introduction. Deposits of various types of asbestos are widespread in the earth’s crust. In these areas there may be a possibility of the atmospheric air pollution by asbestos fibers, especially in the case of industrial development of these deposits or active use by the resident population.

The purpose of this study was to assess the possibility of air pollution by amphibole asbestos fibers in the areas of disused flooded quarries in Sverdlovsk region.

Materials and methods. 5 samples of atmospheric air, water and soil were taken and analyzed at the territories in Sverdlovsk region where magnesio-arfvedsonite and anthophyllite were extracted in the past years.

Results. An extremely high content of free fibers of magnesio-arfvedsonite and anthophyllite (up to 20% of the total weight of the samples) was discovered in the soil samples. The concentrations of asbestos fibers in the water averaged 67 ∙ 10⁶ f/L and 79 ∙ 10⁶ f/L, respectively. The average concentrations of respirable amphibole asbestos fibers were 0.06 f/ml and 0.05 f/ml, respectively.

Limitations. The paper presents the results of a pilot study of air pollution by fibrous particles, based on which it is not possible to give a full description of the situation, taking into account all possible types of anthropogenic activity in the surveyed areas in different seasons of the year.

Conclusion. The results obtained indicate an increased risk of air pollution and water environment contamination by free amphibole asbestos fibers due to their leaching and weathering from rocks, as a result of which disused flooded quarries should be considered as natural and anthropogenic sources of pollution.

It is necessary to conduct regular monitoring of the environmental situation at these facilities, as well as to develop measures to prevent the exposure of amphibole asbestos fibers on the population.

Contribution:

Tskhomariia I.M. — collection of literature data, writing a text;

Kovalevskiy E.V., Kashanskiy S.V. — editing, responsible for approval of the manuscript final version.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship. We express our gratitude to JSC «NIIproektasbest» for their assistance in materials collection.

Received: August 12, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

Introduction. The development of classification and methods for ranking indicators characterizing the state of health of the population is an important direction of development of social and hygienic monitoring in the Russian Federation.

Materials and methods. Analytical, statistical and computational research methods were applied. Statistical materials of the Central Directorate of Health of Russian Railways “Indicators of the health status of employees of Russian Railways, non-working pensioners and the attached territorial population for 2015–2019 were used. The statistical materials of the Department of Monitoring, Analysis and Strategic Development of Health of the Federal State Budgetary Institution “Central Research Institute for the Organization and Informatization of Health” of the Ministry of Health of Russia “Incidence of Adult Population of Russia” for 2015–2019 were also used. In total, more than 115 thousand indicators were analyzed by 18 classes of nosological forms for the five-year period 2015–2019.

Results. The method of scoring priority classes of the primary morbidity of the population according to the criterion of changing the rate of incidence (quantitative criterion) over a time period, as well as according to the criterion of incidence levels compared to indicators in the country, has been developed. The method of scoring was tested on the primary incidence indicators of the attached contingent of Russian Railways compared to the indicators in the country. In the course of social management hygienic monitoring by priority classes of diseases was determined to attach the contingent of OJSC “Russian Railways” are diseases of the ear and mastoid process, diseases of the eye and its appendage apparatus, respiratory diseases.

Limitations. During the scoring of priority nosologies of the primary incidence of railway transport workers and their families, more than 115 thousand indicators were analyzed for 18 classes of nosological forms for the five-year period 2015–2019, which is a sufficient reference sample. We did not analyzed the incidence of the children population attached to the medical organizations of Russian Railways; there was no analysis of incidence depending on sex; the reasons for the higher incidence of employees of Russian Railways and their families compared to the population of the Russian Federation for individual nosologies have not been identified. These criteria were not included in the tasks of this study and may be the subject of future researches.

Conclusions. The developed method of scoring priority classes of primary morbidity of the population, tested on the example of railway transport workers and their families, can be used as one of the methods of classification and ranking of indicators characterizing the state of health of the population.

Contribution:

Loginova V.A. — research concept and design, statistical data processing, design, writing the text, editing;

Kaskov Yu.N. — research concept and design, design, writing the text, editing;

Onishchenko G.G. — research concept and design, design, writing the text,editing, approval of the final version of the article, responsibility for the integrity of all parts of thearticle;

Klimova A.A. — collection and processing of material, statistical data processing.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: January 25, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

Introduction. Distance education means a way of organizing education based on the use of information and communication technologies which make it possible to perform remote learning without a direct face-to-face contact between a teacher and students. The new coronavirus pandemic has caused distance learning to become a reality in the modern education system. However, in the course of application of such a teaching format, it has been revealed electronic digital devices to negatively affect students’ health. However, in the course of such a teaching format, there emerge certain negative factors which influence on the student health. In this regard, there is a need for up-to-date hygiene standards that promote the regulation of education based on distance technologies.

The study objective. To assess the impact of distance learning on the health of students of general educational institutions.

Materials and methods. 135 students of grades 6–8, 10 of general educational organizations were surveyed to identify the features of learning mode and daily routine in general, the information education during distance learning and deviations from the normal state of health. An ophthalmological examination was performed using a Shin Nippon XL-1 hand-held slit lamp, OMEGA 500 Unplugged Binocular Indirect Ophthalmoscope, ophthalmological tonometer «TVGD-02», hardware and software complex KPA-01 «Zrenie».

Results. A revealed negative tendency indicates to the deterioration of the students’ vision over a short period of distance education (November–December 2020) in general educational institutions of the Nizhny Novgorod region. Besides, distance learning triggers physical and emotional overload as well as mental overstrain.

Limitations. The impact of distance learning on children and adolescents’ health was studied on a group of students in grades 6–8, 10 of two general educational institutions in Nizhny Novgorod, which is a sufficiently representative sample.

Conclusion. The obtained results of the study can be used to support the hygienic requirements for the management of distance learning in general educational institutions.

Contribution:

Bogomolova E.S. — concept and design of the study, editing;

Languev K.A. — concept and design of the study, data collection, statistical processing, text writing;

Kotova N.V. — editing.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: October 10, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

Introduction. Horizontal transport of air pollutants by predominant winds plays an important role in the dispersion of emissions from their primary sources.

The purpose of this study is to assess the contribution of prevailing winds to changes of non-invasive markers in preschool children living in a small city at different distances and in different directions from the complex of agricultural processing enterprises.

Materials and methods. Next markers were determined in mixed saliva samples of 112 children (aged 5–7 years) attending 6 kindergartens at distances of 1.74–5.74 km from the source of emissions toward the SSW, SSE and SE: the intensity of luminol-enchanced chemiluminescence (LC), secretory IgA, IL-1β, IL-6, IL-8 levels, and uric acid, α-amylase and N-acetyl-β-D-glucosaminidase activities. Based on the Meteoblue database, integral indicators of wind repeatebility (W, km/year) for winds, blowing towards the town from NNE, NNW and NW correspondingly, were calculated.

Results. As a marker of the effect for multiple regression analysis, the intensity of LC in children’s saliva samples was chosen as having the most pronounced relationship with the distances between kindergartens and the source of emissions (R = –0.524; p = 7•10^–9). The distances were shown to explain 49% of the total variance of LC intensity (p = 3•10^–8), whereas the transfer of emissions with prevailing winds explains 16% of the total variance (p = 0.058). The resulting 3D model is in good agreement with previously conflicting data for two equidistant kindergartens having significant differences in children LC intensity, since corresponding wind repeatebilities differ twofold.

Limitations. To develop the 3D model, archival data were used, with the theoretical possibility of planning a population survey with a more complete coverage of the wind rose points.

Conclusion. The results obtained indicate that it is promising to assess the contribution of prevailing winds when analyzing the data of human health in the industrial areas.

Contributions:

Khripach L.V. — research concept and design, determination of biochemical and immunological indices in saliva samples, wind data adaptation, statistical analysis, interpretation and writing of the manuscript;

Budarina O.V. — research concept and design;

Zheleznyak E.V., Knyazeva T.D., Makovetskaya A.K., Koganova Z.I. — determination of biochemical and immunological indices in saliva samples;

Sabirova Z.F., Shipulina Z.V. — evaluation of expositions.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: July 26, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

Introduction. Poor nutrition is the main cause of nutrition-associated diseases, including iron-deficiency anemia (IDA). An enrichment of basic foods is the one of the most effective preventive measures among the population, especially women and children.

Materials and methods. A survey of 2,218 respondents was conducted to identify public awareness and consumption of enriched flour, of which 1,442 (65%) were women and 776 (35%) were men. The enrichment quality of 408 flour samples was determined according to GOST 26928-86. An epidemiological analysis of the long-term follow up on the prevalence and incidence rates was carried out for the period 2009–2019.

Results. According to the results of the survey, 5.7% of respondents did not know what the term “enriched flour” means, 68.3% consider it “safe flour enriched with vitamins and minerals”. The media were the main sources of information on enriched flour. The majority (30.9%) of the respondents noted the improvement of physical and mental development among the beneficial properties of enriched flour. According to the results of the analysis, 77.4% of Orion brand flour were found to have an underestimated iron content compared with the requirements of the Technical Regulation of the Kyrgyz Republic “On the safety of fortified flour”, 54.8% of Rola flour, 44.7% of Aliya flour. A retrospective analysis of the long-term trend in IDA for the period from 2010 to 2018 revealed a significant decline in the trend by 44.8% (in 2010 — 2373.3 per 100 thousand people, in 2018 —1311.0 per 100 thousand people) among adults and adolescents, and among children from 0 to 14 years of age by 18.4%.

Limitations. The study has potential limitations due to the lack of a comparative analysis of the incidence of iron-deficiency anemia in the population using enriched flour and without, and that not all brands of flour produced domestically and imported were subjected to a full study.

Conclusion. The enrichment of flour with micro-elements is one of the ways to provide functional nutrition. Flour fortification can contribute to strengthening the health of the nation by providing essential vitamins and minerals that are lacking in daily nutrition.

Contribution:

Kochkorova F.A. — the concept and design of the study, collection and processing of material, statistical processing, writing the text, approval of the final version of the article, responsibility for the integrity of all parts of the article.

Toygombaeva V.S. — material processing, consulting, editing.

Esenamanova M.K., Kaliev M.T. — consulting, editing.

Kasymov O.T. — the concept and design of the study, editing, responsibility for the integrity of all parts of the article.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: November 11, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

Introduction. The quality of drinking water in the city of Latacunga and the canton of Pedro Vicente Maldonado was investigated. The health risk assessment related to the use of the studied water after its treatment was carried out.

Materials and methods. Drinking water quality was assessed according to the Ecuadorian and Russian hygiene standards. Methodological recommendations in the study were used to calculate risks for indicators and chemicals characterized by the olfactory-reflex effect of exposure to drinking water, as well as guidelines to assess the risk to public health when exposed to chemicals of a non-carcinogenic and carcinogenic nature. Carcinogenic risk study was conducted by taking into consideration the potentially carcinogenic substances such as trihalomethanes and volatile organic compounds. The chemical safety of drinking water and the effectiveness of water treatment measures were carried out based on an comprehensive assessment of the quality of drinking water.

Results. When analyzing drinking water in the city of Latacunga, exceedance of the Ecuadorian and Russian hygienic standards was revealed in terms of such indicators as phosphates (up to 1.3 TLV), bromoform (up to 1.6 TLV) and dibromochloromethane (up to 4 TLV). According to the criteria for assessing the risk of reflex factors when using drinking water in the city of Latacunga and in the canton of Pedro Vicente Maldonado, the risk of immediate action is at the acceptable level of risk. In accordance with the criteria for assessing the magnitude of the non-carcinogenic risk of chronic exposure to water in the city of Latacunga, assessed by the effect of non-specific action, it can be considered as a matter of concern, and the water of the canton of Pedro Vicente Maldonado can be considered as acceptable. The individual carcinogenic risk in both cities is at an unacceptable carcinogenic risk level. Assessment of the integral indicator of the hazard of drinking water revealed the lack of chemicals safety of drinking water treatment both in the city of Latacunga and in the canton of Pedro Vicente Maldonado and poor efficiency of water treatment.

Limitations. This study does not show the effect of seasonal changes in the course of the integral assessment of drinking water as per chemical safety parameters.

Conclusion. The results obtained underline the need for special attention to the substances formed during disinfection, since high hazard indices are due to the content of trihalomethanes, especially bromodichloromethane and dibromochloromethane.

Contribution:

Salazar Flores C.A. — concept and design of the research, collection and processing of material, statistical processing, writing a text.

Kurbatova A.I., Mikhaylichenko K.Y. — concept and design of the research, editing, writing a text.

Milutka A.C. — editing, writing a text.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. This paper has been supported by the RUDN University Strategic Academic Leadership Program.

Received: November 05, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022

Introduction. At present, both in economically developed and developing countries, there is a trend of too high mortality rates from diseases of the circulatory system. In modern conditions, the activities in health care more apply on the detection and treatment of diseases. So far, special attention needs to be paid to strengthening the personal responsibility of citizens for their own health and targeted sanitary and hygienic training of the population on measures to overcome bad habits by existing medical prevention services.

The purpose of study is to analyze some actual problems of the management of preventive care for the population of the Russian Federation.

In the context of this study, an in-depth analysis of theoretical materials was carried out, during which 21 literature sources and 8 normative legal documents were analyzed, bibliographic, information-analytical method, content analysis and comparative analysis method were used.

The article considers the current state of the management of preventive work among various age groups of the population. Indicators that characterize the quality and availability of this type of assistance are proposed. In the course of the study, an analysis of relevant publications and individual regulatory legal documents determining the procedure and management of preventive measures in Russia was carried out.

Conclusions. To date, no an information environment created to contribute to the formation of a healthy lifestyle culture among the population, especially among young people. An objective situation of disinterest of the population in taking care of their own health remains. Often there is no personal responsibility of people for their health. The formation of a unified systematic approach to the management of preventive activities will improve the quality of medical services to the population of various age categories.

Conflict of interest. The author declares no conflict of interests.

Acknowledgment.  The study had no financial support.

Received: November 10, 2021 / Accepted: November 25, 2021 / Published: April 08, 2022