Homeostatic effect of silicon waters

Introduction. There are considered drinking and mineral waters in terms of homeostatic action (hormesis) of water-soluble silicon and the trends of its biological activity and possible negative effects on the human body.

Materials and methods. In studied waters the concentration of the systemic homeostatic regulator — peroxide anion-radical was measured by the kinetic chemiluminescent method. The water biological activity was assessed by the extrasubstrate synthesis of adenosine triphosphate by the ATP synthase of microorganisms E.Coli K12 TG1(pF1) with built-in genes for the complete CDABE lux operon of the bacteria V. fischeri 6E luminescent system. The parametrization of the water structural-energy state was carried out according to the cryophysical capillary technique. The study object were low-mineralized drinking water packed in 9-liter polymer containers with an initial silicon content of 12 mg/dm³.

Results. The hormetic effect of silicon waters due to self-induction of peroxide anion radicals in water manifests itself in the form of mitochondrial activity and enzyme complexes stimulation, accompanied by activation of the central nervous system, maintenance of nonspecific immunity, and the reproductive system functioning. The degree of silicon water beneficial effect due to the electron-donor and regulatory action of peroxide anion-radicals associates, depends on activation processes during the production and drinking water storage.

Limitations. Recommendations for maintaining the biological activity of silica waters do not go beyond the limits established by existing regulatory documents on the safety of drinking waters.

Conclusion. The levels of radical anion peroxide production (2.6–5.2 μg/dm³), obtained in the course of this study, correspond to the maximum changes in the biological activity of water activation in the range of 1.4–3.0 (relative to the control — distilled water) in the mode of implementing the conditions of non-local activation. With long-term storage in a polymer container, the ability to activate is lost — such water becomes biologically inert. 

Compliance with ethical standards. The study does not require the submission of a biomedical ethics committee opinion or other documents.

Contribution:
Stekhin A.A. — the design of the study, verification of critical content, writing the text, approval of the final version of the article;
Yakovleva G.V. — scientific editorial staff of the manuscript text, data processing;
Nikiforova T.I. — a review of publications on the study.
All co-authors — responsibility for the integrity of all parts of the article.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: December 7, 2022 / Accepted: March 24, 2023 / Published: April 20, 2023