On the issue of the toxic effect of bromine and its inorganic compounds on the body (literature review)

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Abstract

The study of the influence of various chemical elements on the human body is a relevant area, since it allows detecting the patterns of distribution and migration of these elements in tissues, as well as their role in the development of specific diseases. Among inorganic chemicals, a special place is occupied by bromine and its inorganic compounds widely used in industry, agriculture, and medicine. The search and selection of literature sources to identify the physiological effects and features of the toxic impact of bromine and bromide compounds on the human body and experimental animals was carried out using bibliographic databases: Scopus, MedLine, Web of Science, PubMed, The Cochrane Library, RISC, Cyberleninka. Data analysis showed bromine and hydrobromic acid to be classified as highly hazardous substances (hazard class 2), and calcium bromide and sodium bromide are considered moderately hazardous ones (hazard class 3). In high concentrations, all substances have an irritating effect. The most affected organs and systems are: central nervous system, respiratory system, gastrointestinal tract, liver, kidneys, thyroid gland, mucous membranes, skin, eyes. They cause a violation of metabolic processes, primarily mineral ones.

Contribution:
Gorohova L.G. – the concept of the study, collection of material, writing the text;
Mikhailova N.N. – editing.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: April 15, 2024 / Accepted: June 19, 2024 / Published: July 31, 2024

About the authors

Larisa G. Gorokhova

Research Institute for Complex Problems of Hygiene and Occupational Diseases; Kuzbass Humanitarian and Pedagogical Institute of the “Kemerovo State University”

Author for correspondence.
Email: ponomarikova@mail.ru
ORCID iD: 0000-0002-0545-631X

MD, PhD, leading researcher, Lab. of molecular genetics and experimental research of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation; Associate Professor of the Department natural science disciplines of the Kuzbass Humanitarian and Pedagogical Institute of the Kemerovo State University, Novokuznetsk, 654041, Russian Federation

e-mail: ponomarikova@mail.ru

Russian Federation

Nadezhda N. Mikhailova

Research Institute for Complex Problems of Hygiene and Occupational Diseases

Email: napmih@mail.ru
ORCID iD: 0000-0002-1127-6980

MD, PhD, DSci., chief researcher, Lab. of molecular genetics and experimental research of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation

e-mail: napmih@mail.ru

Russian Federation

References

  1. Zaichik V.E., Agadzhanyan I.A. Some methodological issues of medical elementology. Vestnik vosstanovitel’noi meditsiny. 2004; (3): 19–23. https://elibrary.ru/sfqqsb (in Russian)
  2. Rikhvanov L.P., Baranovskaya N.V., Ignatova T.N., Sudyko A.F., Sandimirova G.P., Pakhomova N.N. Trace elements in human organs and tissues and their significance for environmental monitoring. Geokhimiya. 2011; 49(7): 738–42. https://doi.org/10.1134/S001670291107007X https://elibrary.ru/ohtqfd (in Russian)
  3. Sinitsyna O.O., Plitman S.I., Ampleeva G.P., Gil’denskiol’d O.A., Ryashentseva T.M. Essential elements and standards for their contents in drinking water. Analiz riska zdorov’yu. 2020; (3): 29–37. https://doi.org/10.21668/health.risk/2020.3.04.eng https://elibrary.ru/lkrues (in Russian)
  4. McCall A.S., Cummings C.F., Bhave G., Vanacore R., Page-McCaw A., Hudson B.G. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture. Cell. 2014; 157(6): 1380–92. https://doi.org/10.1016/j.cell.2014.05.009
  5. Mashkovskii M.D. Medicines [Lekarstvennye sredstva]. Moscow: Novaya Volna; 2005. (in Russian)
  6. Verkhovskaya I.N. Bromine In a Living Organism and Its Mechanism of Action [Brom v zhivom organizme i mekhanizm ego deistviya]. Moscow: Academy of Sciences of the USSR; 1962. (in Russian)
  7. Polyanskii N.G. Analytical Chemistry of Bromine [Analiticheskaya khimiya broma]. Moscow: Nauka; 1980. (in Russian)
  8. Gribble G.W. The diversity of naturally occurring organobromine compounds. Chem. Soc. Rev. 1999; 28(5): 335–46. https://doi.org/10.1039/A900201D
  9. Lidin R.A., Molochko V.A., Andreeva L.L. Chemical Properties of Inorganic Substances [Khimicheskie svoistva neorganicheskikh veshchestv]. Moscow: Khimiya; 2000. (in Russian)
  10. Avtsyn A.P., Zhavoronkov A.A., Rish M.A., Strochkova L.S. Human Microelementoses: Etiology, Classification, Organopathology [Mikroelementozy cheloveka: etiologiya, klassifikatsiya, organopatologiya]. Moscow: Meditsina; 1991. (in Russian)
  11. Baranovskaya N.V., Perminova T.A., Laratt B., Narkovich D.V., Denisova O.A. Biogeochemical features of the accumulation of bromine in the human body (example of Tomsk region). Vestnik Omskogo gosudarstvennogo agrarnogo universiteta. 2016; (3): 155–64. https://elibrary.ru/wlsmqf (in Russian)
  12. Perminova T.A., Baranovskaya N.V., Bertran L., Zhornyak L.V., Sudyko A.F. Bromine in soils of the Tomsk region. Izvestiya Tomskogo politekhnicheskogo universiteta. Inzhiniring georesursov. 2017; 328(2): 36-45. https://elibrary.ru/yjhfkj (in Russian)
  13. Voinar A.I. Biological Role of Microelements in the Body of Animals and Humans [Biologicheskaya rol’ mikroelementov v organizme zhivotnykh i cheloveka]. Moscow: Nauka; 1960. (in Russian)
  14. Roslyakov N.P. Biological Role of Microelements [Biologicheskaya rol’ mikroelementov]. Moscow: Nauka; 1983. (in Russian)
  15. Vobecký M., Babický A., Lener J. Effect of increased bromide intake on iodine excretion in rats. Bio. Trace Elem. Res. 1996; 55(3): 215–9. https://doi.org/10.1007/bf02785280
  16. Sullivan J.B., Krieger G.R. Clinical Environmental Health and Toxic Exposures. Philadelphia: Lippincott, Williams & Wilkins; 2001.
  17. IPCS INCHEM. Poisons Information Monographs, Bromine (PIM 080); 2007.
  18. Stepanov A.D., Ruina K.S., Kutlubaev A.I. Biological functions of bromine in the human body (review). In: Fundamental Research in the Field of Chemistry, Biology and Ecology. Materials of the International Student Scientific and Practical Conference [Fundamental’nye issledovaniya v oblasti khimii, biologii i ekologii. Materialy mezhdunarodnoi studencheskoi nauchno-prakticheskoi konferentsii]. Orenburg; 2022: 141–4. https://elibrary.ru/irwtmo (in Russian)
  19. Lazarev N.V., Levina E.N. Harmful Substances in Industry: in 3 Volumes. Volume 1 [Vrednye veshchestva v promyshlennosti: v 3-kh tomakh. Tom 1]. Leningrad: Khimiya; 1977. (in Russian)
  20. Pavelka S., Babický A., Vobecký M., Lener J., Svandová E. Bromide kinetics and distribution in the rat. I. Biokinetics of 82Br-bromide. Biol. Trace Elem. Res. 2000; 76(1): 57–66. https://doi.org/10.1385/bter:76:1:57
  21. Seiler H.G., Sigel H., Sigel A. Handbook on the Toxicity of Inorganic Compounds. New York: Marcel Dekker; 1988.
  22. Deichmann W.B., Gerarde H.W. Toxicology of Drugs and Chemicals. New York: Academic Press; 1969.
  23. Bitron M.D., Aharonson E.F. Delayed mortality of mice following inhalation of acute doses of CH2O, SO2Cl2, and Br2. Am. Ind. Hyg. Assoc. J. 1978; 39(2): 129–38. https://doi.org/10.1080/0002889778507726
  24. Handbook of Toxicology. Philadelphia, London: W.B. Saunders; 1959.
  25. Izmerov N.F., Sanotskii I.V., Sidorov K.K. Toxicometry Parameters of Industrial Poisons after a Single Exposure [Parametry toksikometrii promyshlennykh yadov pri odnokratnom vozdeistvii]. Moscow: Meditsina; 1977. (in Russian)
  26. European Commission. European Chemical Substances Information System (ESIS). IUCLID Dataset, Bromine; 2014.
  27. Leri A.C., Hettithanthri O., Bolan S., Zhang T., Unrine J., Myneni S., et al. Bromine contamination and risk management in terrestrial and aquatic ecosystems. J. Hazard. Mater. 2024; 469: 133881. https://doi.org/10.1016/j.jhazmat.2024.133881
  28. Bitron M.D., Aharonson E.F. Delayed mortality of mice following inhalation of acute doses of CH2O, SO2Cl2, and Br2. Am. Ind. Hyg. Assoc. J. 1978; 39(2): 129–38. https://doi.org/10.1080/0002889778507726
  29. Klyachina A.M. The role of specific lesions of the respiratory system in the formation of chronic intoxication with irritating gases: Diss. Moscow; 1974. (in Russian)
  30. Bingham E., Cohrssen B., Powell C.H. Patty’s Toxicology. New York: John Wiley & Sons; 2000.
  31. Inagaki N., Ishikawa M., Takeda M., Abe M., Imai K., Kadoyama T., et al. Case with bromine exposure leading to respiratory insufficiency. Chudoku Kenkyu. 2005; 189(2): 141–7.
  32. Morabia A., Selleger C., Conne P., Landry J.C., Fabre J. Bromine cloud in Geneva. Epidemiologic study of the short-term effects on a population sample. Schweiz Med. Wochenschr. 1986; 116(1): 11–8. (in French)
  33. Shapovalov Yu.D. Biologic effects of elementary bromine and its compounds in industrial workers. Vrachebnoe delo. 1974; (12): 110–5. https://elibrary.ru/zydfnj (in Russian)
  34. Van Leeuwen F.X., den Tonkelaar E.M., van Logten M.J. Toxicity of sodium bromide in rats: effects on endocrine system and reproduction. Food Chem. Toxicol. 1983; 21(4): 383–9. https://doi.org/10.1016/0278-6915(83)90092-3
  35. Rauws A.G., van Logten M.J. The influence of dietary chloride on bromide excretion in the rat. Toxicology. 1975; 3(1): 29–32. https://doi.org/10.1016/0300-483x(75)90005-0
  36. European Commission. ESIS. IUCLID Dataset, Sodium bromide; 2010.
  37. Vaiseman N., Koren G., Pencharz P. Pharmacokinetics of oral and intravenous bromide in normal volunteers. J. Toxicol. Clin. Toxicol. 1986; 24(5): 403–13. https://doi.org/10.3109/15563658608992603
  38. Sangster B., Krajnc E.I., Loeber J.G., Rauws A.G., van Logten M.J. Study of sodium bromide in human volunteers, with special emphasis on the endocrine system. Hum. Toxicol. 1982; 1(4): 393–402. https://doi.org/10.1177/096032718200100405
  39. Van Gelderen C.E., Savelkoul T.J., Blom J.L., van Dokkum W., Kroes R. The no-effect level of sodium bromide in healthy volunteers. Hum. Exp. Toxicol. 1993; 12(1): 9–14. https://doi.org/10.1177/096032719301200102
  40. Gross F., Tripod J., Meier R. Pharmacological characteristics of the soporific doriden. Schweiz Med. Wochenschr. 1955; 85(13): 305–9. (in German)
  41. Barnes Ch.D., Eltherington L.G. Drug Dosage in Laboratory Animals: A Handbook. Berkeley: University of California press; 1973.
  42. Voss E., Haskell A.R., Gartenberg L. Reduction of tetramine toxicity by sedatives and anticonvulsants. J. Pharm. Sci. 1961; 50: 858–60. https://doi.org/10.1002/jps.2600501014
  43. Van Logten M.J., Wolthuis M., Rauws A.G., Kroes R. Short-term toxicity study on sodium bromide in rats. Toxicology. 1973; 1(4): 321–7. https://doi.org/10.1016/0300-483x(73)90038-3
  44. Shafirov Iu.B., Khovakh I.M., Shamrova L.D. Toxicity of sodium bromide for animals. Farmakologiya i toksikologiya. 1970; 33(5): 620–2. (in Russian)
  45. Buchberger W., Holler W., Winsauer K. Effects of sodium bromide on the biosynthesis of thyroid hormones and brominated/iodinated thyronines. J. Trace Elem. Electrolytes. Health Dis. 1990; 4(1): 25–30.
  46. Vobecký M., Pavelka S., Babický A. Bromide transfer through mother’s milk and its impact on the suckling rat. Biol. Trace Elem. Res. 2005; 103(1): 37–48. https://doi.org/10.1385/bter:103:1:037
  47. Disse M., Joó F., Schulz H., Wolff J.R. Prenatal exposure to sodium bromide affects the postnatal growth and brain development. J. Hirnforsch. 1996; 37(1): 127–34.
  48. Hoefel I.R., Camozzato F.O., Hagemann L.N., BohnRhoden D.L., Kiszewski A.E. Bromoderma in an infant. Ann. Bras. Dermatol. 2016; 95(5 Suppl. 1): 17–9. https://doi.org/10.1590/abd1806-4841.20165013
  49. Hsieh P.F., Tsan Y.T., Hung D.Z., Hsu C.L., Lee Y.C., Chang M.H. Bromism caused by mix-formulated analgesic injectables. Hum. Exp. Toxicol. 2007; 26(12): 971–3. https://doi.org/10.1177/0960327107087797
  50. Lewis R.J. Sax’s Dangerous Properties of Industrial Materials. Hoboken, NJ: Wiley-Interscience; 2004. https://doi.org/10.1002/0471701343
  51. European Chemicals Agency (ECHA). Registered Substances, Calcium bromide (CASNumber: 7789-41-5) (ECNumber: 232-164-6); 2019.
  52. National Research Council. Prudent Practices for Handling Hazardous Chemicals in Laboratories. Washington: National Academy Press; 1981.
  53. Braker W., Mossman A. L. Matheson Gas Data Book. Lyndhurst: Matheson; 1980.
  54. Kraut A., Lilis R. Chemical pneumonitis due to exposure to bromine compounds. Chest. 1988; 94(1): 208–10. https://doi.org/10.1378/chest.94.1.208
  55. Burns M.J., Linden C.H. Another hot tub hazard. Toxicity secondary to bromine and hydrobromic acid exposure. Chest. 1997; 111(3): 816–9. https://doi.org/10.1378/chest.111.3.816
  56. European Chemicals Agency (ECHA). Registered Substances, Hydrogen Bromide (CAS Number: 10035-10-6) (EC Number: 233-113-0) (Last modified: September 21, 2018); 2019.
  57. Stavert D.M, Archuleta D.C., Behr M.J., Lehnert B.E. Relative acute toxicities of hydrogen fluoride, hydrogen chloride, and hydrogen bromide in nose- and pseudo-mouth-breathing rats. Fundam. Appl. Toxicol. 1991; 16(4): 636–55. https://doi.org/10.1016/0272-0590(91)90152-t
  58. Ehmann W.D., Vance D.E. Studies of trace element involvement in human disease by in vitro activation analysis. J. Radioanal. Nucl. Chem. 1996; 203(2): 429–45. https://doi.org/10.1007/BF02041521
  59. Lin S.M., Chiang C.H., Huang C.H., Tseng C.L., Yang M.H. Instrumental neutron activation analysis of urinary calculi. J. Radioanal. Nucl. Chem. 1985; 96(2): 153–60. https://doi.org/10.1007/BF02163081

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