Postoperative pain relief quality after cesarean section using a stress monitor (Neon FSC system): prospective single-center randomized clinical comparative study

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Abstract

BACKGROUND: The objective assessment of pain levels during labor, postpartum period, and effectiveness of analgesic response remains difficult. We suppose that the dynamics of the activity of the sympathetic nervous system by measuring the galvanic skin response may become a promising method for solving this problem.

OBJECTIVE: To evaluate the effectiveness of various multimodal analgesia regimens after cesarean section using the NeonFSC stress monitoring system.

MATERIALS AND METHODS: A prospective single-center clinical comparative study was conducted to evaluate the effectiveness of various postoperative multimodal analgesia regimens in 48 postpartum women who underwent elective cesarean section under spinal anesthesia. For postoperative analgesia, group 1 (n=24) underwent a TAP block, and ketorolac and tramadol were prescribed, and group 2 (n=24) received only ketorolac and tramadol. Randomization was made using the envelope method. The visual analog scale (VAS) and NeonFSC system were used to assess the effectiveness of postoperative pain relief. The observation time was 19–22 h.

RESULTS: The patients were comparable in age, gestational age, physical status, method of pain management and delivery. At baseline and during the 2-h postoperative period, the median and distribution of visual analogue scale pain scores did not show a statistically significant difference between groups. During the study period, the highest level of spectral power of skin conductance (SC) was recorded in group 2. Baseline skin conductance variability (SCV) values were comparable between groups (p >0.001). Lower SCV values were noted in patients of group 1, compared to group 2, at night (p=0.003 vs p <0.001). The median values of the level of total spectral power of skin conductivity (DASS) in patients of group 1 were 1.5–2 times lower, starting from the second hour until the end of observation.

CONCLUSION: The NeonFSC system can be a component of an objective assessment of the effectiveness of analgesia after cesarean section.

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About the authors

Ekaterina Yu. Upryamova

Research Institute of Obstetrics and Gynecology named after D.O. Ott

Email: katerinaupryamova@gmail.com
ORCID iD: 0000-0002-7057-2149
SPIN-code: 5925-0041

MD, Dr. Sci. (Med.), department head

Russian Federation, Saint Petersburg

Efim M. Shifman

Vladimirsky Moscow Regional Research Clinical Institute

Email: eshifman@mail.ru
ORCID iD: 0000-0002-6113-8498
SPIN-code: 4582-8494

MD, Dr. Sci. (Med.), Professor, department professor, vice-president of the All-Russian Public Organization «Federation of Anesthesiologists and Reanimatologists»

Russian Federation, Moscow

Pavel A. Degtyarev

Botkin City Clinical Hospital

Email: p.degtyarev@mail.ru
ORCID iD: 0000-0003-1613-3476
SPIN-code: 4120-1753

clinical resident

Russian Federation, Moscow

Vera D. Snezhko

Moscow Regional Research Institute of Obstetrics and Gynecology

Email: Verullia@list.ru
ORCID iD: 0000-0001-6623-9637
SPIN-code: 3326-8726

anesthesiologist-resuscitator

Russian Federation, Moscow

Tatyana A. Maksimkina

Moscow Regional Research Institute of Obstetrics and Gynecology

Author for correspondence.
Email: tatianazob@mail.ru
ORCID iD: 0009-0000-4100-2115

anesthesiologist-resuscitator

Russian Federation, Moscow

References

  1. Carvalho B, Cohen SE. Measuring the labor pain experience: delivery still far off. Int J Obstet Anesth. 2013;22(1):6–9. doi: 10.1016/j.ijoa.2012.10.002
  2. Tournaire M, Theau-Yonneau A. Complementary and Alternative Approaches to Pain Relief During Labor. Evid Based Complement Alternat Med. 2007;4(4):409–417. doi: 10.1093/ecam/nem012
  3. Theodoros A. Electrodermal activity: Applications in perioperative care. Int J Med Res Health Sci. 2014;3(3):687–695. doi: 10.5958/2319-5886.2014.00418.4
  4. Burton AR, Birznieks I, Spaak J, et al. Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjects. Exp Brain Res. 2009;195(2):317–324. doi: 10.1007/s00221-009-1790-9
  5. Nickel MM, May ES, Tiemann L, et al. Autonomic responses to tonic pain are more closely related to stimulus intensity than to pain intensity. Pain. 2017;158(11):2129–2136. doi: 10.1097/j.pain.0000000000001010

Supplementary files

Supplementary Files
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2. Fig. 1. Comparison of the dynamics of the IP level (intensity of the stressor) between groups at the stages of the study

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3. Fig. 2. Comparison of the dynamics of the PV level (an indicator of autonomic reactivity) between groups at the stages of the study

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4. Fig. 3. Comparison of the dynamics of the DASS level (cumulative effect of stress) between groups at the study stages

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5. Fig. 4. The structure of correlations between pain assessment indicators (VAS, IP, PV, DASS and CSP) Note. *** — p <0.001, TAR — 1st group (TAP block), НА — 2nd group (opioid analgesics).

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