EFFECTIVENESS OF INTRAVENOUS INFLUENCE OF LIDOCAIN AT ANALGEESIA AFTER VIDEO-ASSISTED TORACCOSCOPIC LOBECTOMY

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Abstract

Objective: Effect of perioperative intravenous lidocaine infusion after video-assissed toraxoscopic lobectomy. Materials and methods. 90 patients who underwent lobectomy with a video assisted thoracoscopic method were examined. In the first group (n = 30) for analgesia, intravenous infusion of lidocaine was used, in the second group (n = 30) - narcotic analgesics, in the third group (n = 30) epidural analgesia was used. An evaluation of the extubation time and the severity of the perspiratory response to the endotracheal tube was performed. The intensity of the postoperative pain syndrome was assessed on a 10-point visual analogue scale every 15 minutes for an hour, then every 4 hours after the first day. In all groups, during the first 24 hours, the consumption of narcotic analgesics was recorded, as well as the frequency of postoperative nausea and vomiting and the need for rehabilitation bronchoscopy. Results. The time of extubation in patients of the 1 st group was significantly greater than in the patients of the 2 nd and 3 rd groups. In patients of the 1 st group, the severity of the pressor response to extubation was significantly lower. The strength of pain in rest and motion, as well as the overall postoperative need for analgesics (promedol) were significantly lower (30.1 ± 2.25 mg and 51.1 ± 9.16 mg compared to 122.2 ± 14.18 mg, in groups of epidural analgesia and lidocaine group.In the postoperative period, there was a significantly lower level of postoperative nausea and vomiting in patients of Group I. The need for sanation PBS was noted in 2 (6.7%) patients in Group 1 and 5 (16.7%) patients in Group 2. In patients of the 3rd group, sanation bronchoscopy was not performed. Conclusion. An intravenous infusion of lidocaine at anesthesiology maintenance operations on light has a marked analgesic effect, which by its severity inferior epidural block, but greater than the systemic administration of narcotic analgesics, has opiodsberegayuschim effect, reduces the incidence of postoperative nausea and vomiting, is not accompanied by clinical signs of systemic local anesthetic toxicity. Infusion of lidocaine as a method of analgesia can be utilized in the case where the execution epidural impossible or not desirable.

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About the authors

Vasiliy A. Zhikharev

Scientific Research Institution named after S.V. Ochapovsky Regional Clinic Hospital № 1

Email: Vasilii290873@yandex.ru
senior registrar of the Department of Anesthesia and Intensive Care № 1, Scientific Research Institute named after Ochapovsky Regional Clinic Hospital №1, 350086, Krasnodar, Russian Federation 350081, Krasnodar, Russian Federation

A. S Bushuev

Scientific Research Institution named after S.V. Ochapovsky Regional Clinic Hospital № 1

350081, Krasnodar, Russian Federation

I. Yu Sholin

Scientific Research Institution named after S.V. Ochapovsky Regional Clinic Hospital № 1

350081, Krasnodar, Russian Federation

V. A Koriachkin

North-West State Medical University named after I.I. Mehnikov

195067, St. Petersburg, Russian Federation

References

  1. Grass J.A. The role of epidural anesthesia and analgesia in postoperative outcome. Anesthesiol Clin N Am. 2000; 18: 407-28.
  2. Kolettas A., Lazaridis G., Baka S., Mpoukovinas I., Karavasilis V., Kioumis I. et al. Postoperative pain management. J Thorac Dis. 2015; 7: 62-72.
  3. Terkawi A.S., Tsang S., Kazemi A.A. Clinical Comparison of Intravenous and Epidural Local Anesthetic for Major Abdominal Surgery. Regional anesthesia and pain medicine. 2016; 41 (1): 28-36.
  4. Bhiken I. Naik, Siny Tsang, Anne Knisely, Sandeep Yerra, Marcel E. Durieux. Retrospective case-control non-inferiority analysis of intravenous lidocaine in a colorectal surgery enhanced recovery program. BMC Anesthesiol. 2017; 17 (1): 16.
  5. Ibrahim A., Aly M., Farrag W. Effect of intravenous lidocaine infusion on long-term postoperative pain after spinal fusion surgery. Medicine (Baltimore). 2018; 97 (13): 2-29.
  6. Vigneault L., Turgon A.F., Cote D. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Can J Anesth. 2011; 58: 22-37.
  7. McCarthy G.C., Megalla S.A., Habib A.S. Impact of Intravenous Lidocaine Infusion on Postoperative Analgesia and Recovery from Surgery. Drugs. 2010; 70 (9): 1149-63.
  8. Kaba A., Laurent S., Detroz B. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology. 2007; 106: 11-8.
  9. Корячкин В.А., Страшнов В.И. Анестезия и интенсивная терапия. СПб.: Санкт-Петербургское медицинское издательство; 2004. 465 с.
  10. Vigneault L., Turgon A.F., Cote D. et al. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Can J Anesth. 2011; 58: 22-37.
  11. Barreveld A., Witte J., Chahal H., Durieux M.E., Strichartz G. Preventive analgesia by local anesthetics: the reduction of postoperative pain by peripheral nerve blocks and intravenous drugs. Anesth Analg. 2013; 116: 1141-61.
  12. Herminghaus A., Wachowiak M., Wilhelm W., Gottschalk A., Eggert K., et al. Intravenös verabreichtes Lidocain zur perioperativen Schmerztherapie. Der Anaesthesist. 2011; 2: 152-60.
  13. McCarthy G.C., Megalla S.A., Habib A.S. Impact of Intravenous Lidocaine Infusion on Postoperative Analgesia and Recovery from Surgery. Drugs. 2010; 70 (9): 1149-63.
  14. Habibi M.R., Habibi V., Habibi A., Soleimani A. Lidocaine dose-response effect on postoperative cognitive deficit: meta-analysis and meta-regression. Expert Rev Clin Pharmacol. 2018; 11 (4): 361-71.
  15. Cui W., Li Y., Li S., Wang R., Li J. Systemic administration of lidocaine reduces morphine requirements and postoperative pain of patients undergoing thoracic surgery after propofol-remifentanil-based anaesthesia. Eur J Anaesthesiol. 2010; 27: 41-6.
  16. Slovack M., Taylor B., Bryce R., Ong D. Does intravenous lidocaine infusion during video-assisted thoracoscopic surgery reduce postoperative analgesia? A randomized controlled study. Can J Anesth. 2015; 62 (6): 676-7.
  17. Cheng G.S., Ilfeld B.M. An Evidence-Based Review of the Efficacy of Perioperative Analgesic Techniques for Breast Cancer-Related Surgery. Pain Med. 2017; 18 (7): 1344-65.
  18. Herminghaus A., Wachowiak M., Wilhelm W., Gottschalk A., Eggert K. Intravenös verabreichtes Lidocain zur perioperativen Schmerztherapie. Der Anaesthesist. 2011; 2: 152-60.
  19. Страшнов В.И., Забродин О.Н., Мамедов А.Д., Страшнов А.В., Корячкин В.А. Предупреждение интраоперационного стресса и его последствий. СПб.: ЭЛБИ-СПб, 2015. 160 с.
  20. Kurabe M., Furue H., Kohno T. Intravenous administration of lidocaine directly acts on spinal dorsal horn and produces analgesic effect: An in vivo patch-clamp analysis. Scientific reports. 2016; 6: 26253.
  21. van der Wal S.E., van den Heuvel S.A., Radema S.A., van Berkum B.F., Vaneker M. et al. The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain. Eur J Pain. 2016; 20: 655-74.
  22. Yang W., Geng Y., Liu Y., Li A., Liu J. et al. Comparison of Effects of Thoracic Epidural and Intravenous Administration of Lidocaine on Target-Controlled Infusion of Propofol and Tracheal Intubation Response During Induction of Anesthesia. Journal of Cardiothoracic and Vascular Anesthesia. 2013; 27 (6): 1295-300.
  23. Корячкин В.А., Чуприс В.Г., Черный А.Ж., Казарин В.С., Лиськов М.А. и др. Системная токсичность местных анестетиков при регионарной анестезии в ортопедии и травматологии. Травматология и ортопедия России. 2015; 1 (75): 129-35.
  24. Jolly E.R., Steinhaus J.E. The effect of drugs injected into limited portions of the cerebral circulation. J Pharmacol Exp Ther. 1956; 116: 273-81.
  25. Nath P., Williams S., Herrera Méndez L.F., Massicotte N., Girard F., Ruel M. Alkalinized Lidocaine Preloaded Endotracheal Tube Cuffs Reduce Emergence Cough After Brief Surgery: A Prospective Randomized Trial. Anesth Analg. 2018; 126 (2): 615-20.

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