Email this article Neuropathic pain treatment with xenon
- Authors: Khinovker V.V.1,2, Veselova O.F.1,2,3, Khinovker E.V.2, Koryachkin V.A.3
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Affiliations:
- Federal Siberian Research Clinical Centre
- Krasnoyarsk State Medical University
- Saint-Petersburg State Pediatric Medical University
- Issue: Vol 16, No 2 (2022)
- Pages: 151-159
- Section: Original study articles
- URL: https://rjraap.com/1993-6508/article/view/108649
- DOI: https://doi.org/10.17816/RA108649
- ID: 108649
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Abstract
THE AIM: This study aimed to evaluate the effects of xenon on neuropathic pain during parapulmonal injections in the rat model. Xenon is a drug for inhalation anesthesia that is assumed to have an analgesic effect when administered parapulmonary (similar to nitrous oxide and cyclopropane) and can later be used as an alternative analgesic drug in patients with pain syndrome that is not controlled by standard methods.
MATERIALS AND METHODS: The experiment used in vivo model of neuropathic pain by Bennet and Xie (1988) on rats with sciatic nerve transection. Additionally, a special scoring was adopted based on known behavioral changes of experimental animals (self-harm of limbs, neatness, activity, and bedding conditions). The control group was subcutaneously administered air daily for 5 days, and the experimental group received medical xenon at 40 ml/kg. The pain was assessed with the subcutaneous introduction of air and xenon in the experimental and control groups.
RESULTS: Study results revealed that rats from the experimental group (xenon) showed fewer signs of neuropathic pain syndrome development compared to the control group (air).
CONCLUSION: Therefore, parapulmonal injections of xenon showed a high analgesia effect in animal models of chronic neuropathic pain.
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About the authors
Vladimir V. Khinovker
Federal Siberian Research Clinical Centre; Krasnoyarsk State Medical University
Author for correspondence.
Email: vhinov@hotmail.com
ORCID iD: 0000-0002-3162-6298
SPIN-code: 8640-9591
MD, Cand. Sci. (Med.)
Russian Federation, Krasnoyarsk; KrasnoyarskOlga F. Veselova
Federal Siberian Research Clinical Centre; Krasnoyarsk State Medical University; Saint-Petersburg State Pediatric Medical University
Email: veselovaof@mail.ru
ORCID iD: 0000-0002-6126-665X
SPIN-code: 4340-0455
MD, Cand. Sci. (Med.)
Russian Federation, Krasnoyarsk; Krasnoyarsk; Saint-PetersburgEkaterina V. Khinovker
Krasnoyarsk State Medical University
Email: khinov@mail.ru
ORCID iD: 0000-0002-8860-9480
SPIN-code: 7440-1924
Russian Federation, Krasnoyarsk
Viktor A. Koryachkin
Saint-Petersburg State Pediatric Medical University
Email: vakoryachkin@mail.ru
ORCID iD: 0000-0002-3400-8989
SPIN-code: 6101-0578
MD, Dr. Sci. (Med.), professor
Russian Federation, Saint-PetersburgReferences
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