Neuropathic pain treatment with xenon

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Abstract

THE AIM: This study aimed to evaluate the effects of xenon on neuropathic pain during parapulmonal injections in the rat model. Xenon is a drug for inhalation anesthesia that is assumed to have an analgesic effect when administered parapulmonary (similar to nitrous oxide and cyclopropane) and can later be used as an alternative analgesic drug in patients with pain syndrome that is not controlled by standard methods.

MATERIALS AND METHODS: The experiment used in vivo model of neuropathic pain by Bennet and Xie (1988) on rats with sciatic nerve transection. Additionally, a special scoring was adopted based on known behavioral changes of experimental animals (self-harm of limbs, neatness, activity, and bedding conditions). The control group was subcutaneously administered air daily for 5 days, and the experimental group received medical xenon at 40 ml/kg. The pain was assessed with the subcutaneous introduction of air and xenon in the experimental and control groups.

RESULTS: Study results revealed that rats from the experimental group (xenon) showed fewer signs of neuropathic pain syndrome development compared to the control group (air).

CONCLUSION: Therefore, parapulmonal injections of xenon showed a high analgesia effect in animal models of chronic neuropathic pain.

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About the authors

Vladimir V. Khinovker

Federal Siberian Research Clinical Centre; Krasnoyarsk State Medical University

Author for correspondence.
Email: vhinov@hotmail.com
ORCID iD: 0000-0002-3162-6298
SPIN-code: 8640-9591

MD, Cand. Sci. (Med.)

Russian Federation, Krasnoyarsk; Krasnoyarsk

Olga F. Veselova

Federal Siberian Research Clinical Centre; Krasnoyarsk State Medical University; Saint-Petersburg State Pediatric Medical University

Email: veselovaof@mail.ru
ORCID iD: 0000-0002-6126-665X
SPIN-code: 4340-0455

MD, Cand. Sci. (Med.)

Russian Federation, Krasnoyarsk; Krasnoyarsk; Saint-Petersburg

Ekaterina V. Khinovker

Krasnoyarsk State Medical University

Email: khinov@mail.ru
ORCID iD: 0000-0002-8860-9480
SPIN-code: 7440-1924
Russian Federation, Krasnoyarsk

Viktor A. Koryachkin

Saint-Petersburg State Pediatric Medical University

Email: vakoryachkin@mail.ru
ORCID iD: 0000-0002-3400-8989
SPIN-code: 6101-0578

MD, Dr. Sci. (Med.), professor

Russian Federation, Saint-Petersburg

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Supplementary files

Supplementary Files
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1. Fig. 1. Ischiatic nerve transection.

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2. Fig 2. The mechanism for xenon safe delivery to syringe.

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3. Fig 3. Score and damage level correlation.

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4. Fig. 4. Animals average weight change (control and experimental groups).

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