Possibilities of clinical application of articaine

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Articaine is an intermediate-potency and short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. Articaine was widely used in dental practice, but now has an effective form for surgical and anesthetic use. Articaine is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when intravenously injected for regional anesthesia. Comparative trials have not revealed a generally significant difference in its clinical effects from those of other short-acting local anesthetics, such as lidocaine, prilocaine, and chloroprocaine, and no conclusive evidence has demonstrated above-average neurotoxicity. Thus, this review discusses the pharmacokinetics and pharmacodynamics, clinical efficacy, and possible side effects of articaine.


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Aynagul Zh. Bayalieva

Kazan State Medical University

Author for correspondence.
Email: bayalieva1@yandex.ru
ORCID iD: 0000-0001-7577-3284
SPIN-code: 3098-0228

MD, Dr. Sci. (Med.), professor

Russian Federation, Kazan

Yulia N. Yankovich

Kazan State Medical University

Email: st.ketamine@yandex.ru
ORCID iD: 0000-0002-1399-9672
Russian Federation, Kazan

Munir Mohsin

Kazan State Medical University

Email: dr_mohsin2807@yahoo.com
ORCID iD: 0000-0001-7759-7528
Russian Federation, Kazan

Veronika R. Davydova

Kazan State Medical University

Email: vevojuyar@gmail.com
ORCID iD: 0000-0003-4718-5076
SPIN-code: 3881-2341
Scopus Author ID: 954645
Russian Federation, Kazan


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Supplementary files

Supplementary Files
1. Fig. The structure of the formula of three topical anesthetic drugs, lidocaine, articaine, and procaine.

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