Biphasic Hormetic-like Effect of Lebecetin, a C-type Lectin of Snake Venom, on Formalin-induced Inflammation in Mice

  • Авторы: Belardo C.1, Jebali J.2, Boccella S.3, Infantino R.4, Fusco A.3, Perrone M.5, Bonsale R.4, Manzo I.4, Iannotta M.4, Scuteri D.6, Ferraraccio F.7, Panarese I.7, Ferrara G.7, Guida F.4, Luongo L.4, Palazzo E.4, Srairi-Abid N.8, Marrakchi N.9, Maione S.4
  • Учреждения:
    1. Department of Experimental Medicine, harmacology Division, University of Campania "L. Vanvitelli"
    2. Laboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis, University of Tunis El Manar
    3. Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli
    4. Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli"
    5. Department of Experimental Medicine, Pharmacology Division, University of Campania "L
    6. Pharmacotechnology Documentation and Transfer Unit, Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria
    7. Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania"L. Vanvitelli"
    8. Laboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis,, University of Tunis El Manar,
    9. Laboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis,, University of Tunis El Manar
  • Выпуск: Том 22, № 8 (2024)
  • Страницы: 1391-1405
  • Раздел: Neurology
  • URL: https://rjraap.com/1570-159X/article/view/644874
  • DOI: https://doi.org/10.2174/1570159X22999231207105743
  • ID: 644874

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Аннотация

Background:Integrins, important extracellular matrix (ECM) receptor proteins, are affected by inflammation and can participate in the maintenance of many painful conditions. Although they are ubiquitous and changeable across all cell types, the roles of these cell adhesion molecules in pathological pain have not been fully explored.

Objective:We evaluated the effects of the subcutaneous injection of lebecetin, a C-type lectin isolated from Macrovipera lebetina snake venom, previously reported to inhibit α5β1 and αv integrin activity, on different components of inflammation induced by the formalin administration in the hind paw of mice.

Methods:The formalin-induced nocifensive behavior, edema, and histopathological changes in the hind paw associated with cytokine, iNOS, and COX2 expression, nociceptive-specific neuron activity, and microglial activation analysis in the spinal cord were evaluated in mice receiving vehicle or lebecetin pretreatment.

Results:Lebecetin inhibited the nocifensive responses in the formalin test, related edema, and cell infiltration in the injected paw in a biphasic, hormetic-like, and dose-dependent way. According to that hormetic trend, a reduction in pro-inflammatory cytokines IL-6, IL-8, and TNF-alpha and upregulation of the anti-inflammatory cytokine IL-10 in the spinal cord were found with the lowest doses of lebecetin. Moreover, COX2 and iNOS expression in serum and spinal cord followed the same biphasic pattern of cytokines. Finally, nociceptive neurons sensitization and activated microglia were normalized in the dorsal horn of the spinal cord by lebecetin.

Conclusion:These findings implicate specific roles of integrins in inflammation and tonic pain, as well as in the related central nervous system sequelae.

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Об авторах

Carmela Belardo

Department of Experimental Medicine, harmacology Division, University of Campania "L. Vanvitelli"

Email: info@benthamscience.net

Jed Jebali

Laboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis, University of Tunis El Manar

Email: info@benthamscience.net

Serena Boccella

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli

Email: info@benthamscience.net

Rosmara Infantino

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli"

Email: info@benthamscience.net

Antimo Fusco

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli

Email: info@benthamscience.net

Michela Perrone

Department of Experimental Medicine, Pharmacology Division, University of Campania "L

Email: info@benthamscience.net

Roozbe Bonsale

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli"

Email: info@benthamscience.net

Iolanda Manzo

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli"

Email: info@benthamscience.net

Monica Iannotta

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli"

Email: info@benthamscience.net

Damiana Scuteri

Pharmacotechnology Documentation and Transfer Unit, Preclinical and Translational Pharmacology, Department of Pharmacy, Health and Nutritional Sciences, University of Calabria

Автор, ответственный за переписку.
Email: info@benthamscience.net

Franca Ferraraccio

Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania"L. Vanvitelli"

Email: info@benthamscience.net

Iacopo Panarese

Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania"L. Vanvitelli"

Email: info@benthamscience.net

Giovanna Ferrara

Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania"L. Vanvitelli"

Email: info@benthamscience.net

Francesca Guida

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli"

Email: info@benthamscience.net

Livio Luongo

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli"

Email: info@benthamscience.net

Enza Palazzo

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli"

Email: info@benthamscience.net

Najet Srairi-Abid

Laboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis,, University of Tunis El Manar,

Email: info@benthamscience.net

Naziha Marrakchi

Laboratory of Biomolecules, Venoms and Theranostic Applications, LR20IPT01, Institut Pasteur of Tunis,, University of Tunis El Manar

Email: info@benthamscience.net

Sabatino Maione

Department of Experimental Medicine, Pharmacology Division, University of Campania "L. Vanvitelli"

Автор, ответственный за переписку.
Email: info@benthamscience.net

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