Glymphatic System and Psychiatric Disorders: A Rapid Comprehensive Scoping Review


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Background:Since discovering the glymphatic system, there has been a looming interest in exploring its relationship with psychiatric disorders. Recently, increasing evidence suggests an involvement of the glymphatic system in the pathophysiology of psychiatric disorders. However, clear data are still lacking. In this context, this rapid comprehensive PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) scoping review aims to identify and analyze current evidence about the relation between the glymphatic system and psychiatric disorders.

Methods:We conducted a comprehensive review of the literature and then proceeded to discuss the findings narratively. Tables were then constructed and articles were sorted according to authors, year, title, location of study, sample size, psychiatric disorder, the aim of the study, principal findings, implications.

Results:Twenty papers were identified as eligible, among which 2 articles on Schizophrenia, 1 on Autism Spectrum Disorders, 2 on Depression, 1 on Depression and Trauma-related Disorders, 1 on Depression and Anxiety, 2 on Anxiety and Sleep Disorders, 8 on Sleep Disorders, 2 on Alcohol use disorder and 1 on Cocaine Use Disorder.

Conclusion:This review suggests a correlation between the glymphatic system and several psychiatric disorders: Schizophrenia, Depression, Anxiety Disorders, Sleep Disorders, Alcohol Use Disorder, Cocaine Use Disorder, Trauma-Related Disorders, and Autism Spectrum Disorders. Impairment of the glymphatic system could play a role in Trauma-Related Disorders, Alcohol Use Disorders, Cocaine Use Disorders, Sleep Disorders, Depression, and Autism Spectrum Disorders. It is important to implement research on this topic and adopt standardized markers and radio diagnostic tools.

作者简介

Tommaso Barlattani

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L’Aquila

Email: info@benthamscience.net

Paolo Grandinetti

National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment

Email: info@benthamscience.net

Alexsander Cintio

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L’Aquila

Email: info@benthamscience.net

Alessio Montemagno

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L’Aquila

Email: info@benthamscience.net

Roberta Testa

National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment

Email: info@benthamscience.net

Chiara D’Amelio

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L’Aquila

Email: info@benthamscience.net

Luigi Olivieri

National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment

Email: info@benthamscience.net

Carmine Tomasetti

National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment

Email: info@benthamscience.net

Alessandro Rossi

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L’Aquila

Email: info@benthamscience.net

Francesca Pacitti

Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L’Aquila

编辑信件的主要联系方式.
Email: info@benthamscience.net

Domenico De Berardis

National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment

Email: info@benthamscience.net

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