Synthesis of 1-antipyryl-1H-pyrrol-2-ones by interaction N-antipyryl substituted enamines with oxalyl chloride

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Abstract

Methyl 4-aryl-2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-ylamino)-4-oxo-2-butenoates react with oxalyl chloride to form methyl 3-aroyl-2-chloro-1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-yl)-4-hydroxy-5-oxo-2, 5-dihydro-1 H -pyrrole-2-carboxylates, which are hydrolyzed to methyl 3-aroyl1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-yl)-2,4-dihydroxy-5-oxo-2,5-dihydro-1 H -pyrrole2-carboxylates, the structure of which was confirmed by X-ray diffraction analysis.

About the authors

E. S Denislamova

Perm National Research Polytechnic University

Email: katherin85@rambler.ru

V. A Lyadov

Perm National Research Polytechnic University

Email: katherin85@rambler.ru

D. E Makrushin

Perm National Research Polytechnic University

Email: katherin85@rambler.ru

V. G Ryabov

Perm National Research Polytechnic University

Email: katherin85@rambler.ru

M. V Dmitriev

Perm State University

Email: katherin85@rambler.ru

A. N Maslivets

Perm State University

Email: katherin85@rambler.ru

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