Questions on the role of biofilms for the adaptation of microorganisms to unfavorable environmental factors by the example of P. aeruginosa

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Abstract

Pseudomonas aeruginosa is a widely represented species of bacteria possessing of a pathogenic potential. This infectious agent is causing wound infections, fibrotic cystitis, fibrosing pneumonia, bacterial sepsis, etc. The microorganism is highly resistant to antiseptics, disinfectants, immune system responses of the body. The responses of a quorum sense of this kind of bacteria ensure the inclusion of many pathogenicity factors. The analysis of the scientific literature made it possible to formulate four questions concerning the role of biofilms for the adaptation of P. aeruginosa to adverse environmental factors: Is another person appears to be predominantly of a source an etiological agent or the source of P. aeruginosa infection in the environment? Does the formation of biofilms influence on the antibiotic resistance? How the antagonistic activity of microorganisms is realized in biofilm form? What is the main function of biofilms in the functioning of bacteria? A hypothesis has been put forward the effect of biofilms on the increase of antibiotic resistance of bacteria and, in particular, P. aeruginosa to be secondary in charcter. It is more likely a biofilmboth to fulfill the function of storing nutrients and provide topical competition in the face of food scarcity. In connection with the incompatibility of the molecular radii of most antibiotics and pores in biofilm, biofilm is doubtful to be capable of performing a barrier function for protecting against antibiotics. However, with respect to antibodies and immunocompetent cells, the barrier function is beyond doubt. The biofilm is more likely to fulfill the function of storing nutrients and providing topical competition in conditions of scarcity of food resources.

About the authors

Vasily N. Afonyushkin

Siberian Federal Research Center for Agrobiotechnology

Author for correspondence.
Email: lisocim@mail.ru
ORCID iD: 0000-0001-5177-4733

MD, Ph.D., head of the department of molecular biology Siberian Institute of experimental veterinary science of Siberia and the Far East Siberian Federal Research Center for Agrobiotechnology of the Russian Academy of Sciences, Krasnoobsk, 630501, box 708, Russian Federation.

e-mail: lisocim@mail.ru

Russian Federation

N. A. Donchenko

Siberian Federal Research Center for Agrobiotechnology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-0885-0515
Russian Federation

Ju. N. Kozlova

Institute of Chemical Biology and Fundamental Medicine SB RAS

Email: noemail@neicon.ru
ORCID iD: 0000-0003-0811-8110
Russian Federation

N. A. Davidova

Siberian Federal Research Center for Agrobiotechnology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-4831-2957
Russian Federation

V. Yu. Koptev

Siberian Federal Research Center for Agrobiotechnology

Email: noemail@neicon.ru
ORCID iD: 0000-0003-0537-6659
Russian Federation

V. S. Cherepushkina

Siberian Federal Research Center for Agrobiotechnology

Email: noemail@neicon.ru
ORCID iD: 0000-0002-3378-7335
Russian Federation

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Copyright (c) 2024 Afonyushkin V.N., Donchenko N.A., Kozlova J.N., Davidova N.A., Koptev V.Y., Cherepushkina V.S.


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