Changes in the left ventricle in workers with long work experience of the coal and aluminum industry

Introduction. The leading role in the industrial structure of Kuzbass belongs to the coal and metallurgical industry associated with exposure to harmful production factors and high risks to the health of workers. The main pathogenetic factors triggering occupational and production-related diseases are hypoxic conditions potent of promoting changes in the heart structure and function.

Materials and methods. The study included one hundred sixteen miners and 84 workers in the main occupations of aluminum production. The average age of miners was 47.63±0.33 years, of workers in the aluminum production — 48.41±0.53 years, p=0.191. Work experience in harmful working conditions in the study groups exceeded 20 years and did not differ significantly (p=0.281). All subjects underwent echocardiography according to the standard technique with automatic calculation of the global longitudinal deformity of the left ventricle.

Results. The left ventricular ejection fraction and its longitudinal deformation were lower in aluminum industry workers with arterial hypertension not only in comparison with metallurgists with normal blood pressure (p<0.0001), but also with miners with arterial hypertension (p=0.015). Longitudinal deformation of the left ventricle in aluminum workers without arterial hypertension was significantly lower than in miners with normal blood pressure (p=0.0062). The parameters of the diastolic function of the left ventricle changed in the study groups under the influence of arterial hypertension.

Limitations. This investigation is limited to a selection of workers in the main professions of the aluminum and coal industries undergoing periodic medical examinations at the Research Institute for Complex Problems of Hygiene and Occupational Diseases.

Conclusion. A decrease in global longitudinal left ventricular myocardial deformation in miners and aluminum industry workers was associated with the presence of arterial hypertension and with the specifics of the main adverse production factors. The indices of left ventricular contractile function in aluminum industry workers were significantly lower compared to those in miners, regardless of the presence of arterial hypertension.

Compliance with ethical standards. All subjects signed an informed consent to participate in the study, the protocol of which corresponded to the requirements of the bioethical committee of the Research Institute for Complex Problems of Hygiene and Occupational Diseases, executed in accordance with the Helsinki Declaration of the World Medical Association “Ethical principles for conducting scientific medical researches involving humans” as amended in 2013 and the “Rules of Clinical Practice in the Russian Federation”, approved by the Order of the Ministry of Health of the Russian Federation No. 266 dated 19.06.2003.

Contribution:
Korotenko O.Yu. — the concept and design of the study, collection of material, writing a text;
Filimonov E.S. — collection and processing of material, statistical processing, writing a text;
Panev N.I. — writing a text.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: April 04, 2022 / Accepted: June 08, 2022 / Published: July 31, 2022