Hygienic and chemical-analytical support for the safe use of pesticides of the dithiocarbamate group

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Abstract

Introduction. There is continued trend in recent years of increasing the use of new chemicals, most of which are potential sources of risk to human health. The hygienic assessment of their application in the regions of the Russian Federation using various technologies is becoming more and more relevant. 

The aim of the work was to determine the exposure levels of mankoceb, tiram and metiram (pesticides of the dithiacarbamate group), to establish the threshold of the acceptable risk of exposure to pesticides for workers while complying with technical recommendations and safety requirements.

Materials and methods. The determinations of the mancozeb, thiram and metiram were carried out by the gas-liquid chromatography with a flame-photometric detector (GC, FPD); the risk assessment was carried out by exposure (KBsumm) and absorbed dose (KBp) with a complex intake of active ingredients into the body of workers, under the Methodological Instructions № 1.2.3017-12.

Results. There were analyzed more than 350 samples of air of the working zone and washing from workers’ skin. There was shown an absence of active substances mancozeb and metiram in them. The insignificant content of thiram at a level close to the limit of its quantitative determination was found.

Conclusion. The results obtained allow assessing the risk of safe use of drugs based on dithiocarbamates in agriculture, which is the basis for predicting the total chemical exposure to humans, and accurately evaluating the levels of pollutants.

Contributions:

Larkina M.V. — collection and processing of the material, writing the text, editing, concept and design of the study;

Mikheeva E.N. — collection and processing of the material, writing the text, editing;

Fedorova S.G. — concept and design of the study;

Bondareva L.G. — writing the text, editing.

All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

About the authors

Maria V. Larkina

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Author for correspondence.
Email: analyt1@yandex.ru
ORCID iD: 0000-0002-8570-9769

MD, PhD, Senior researcher, Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing, Mytishchi, 141014, Russian Federation.

e-mail: analyt1@yandex.ru

Russian Federation

Elena N. Mikheeva

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Email: noemail@neicon.ru
ORCID iD: 0000-0002-9633-5686
Russian Federation

Svetlana G. Fedorova

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Email: noemail@neicon.ru
ORCID iD: 0000-0001-8860-5298
Russian Federation

Lidiya G. Bondareva

Federal Scientific Center of Hygiene named after F.F. Erisman of the Federal Service for Supervision in Protection of the Rights of Consumer and Man Wellbeing

Email: noemail@neicon.ru
ORCID iD: 0000-0002-1482-6319
Russian Federation

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