Evaluation of the interrelationships of indicators characterizing neurofunctional activity in vibration disease

Introduction. The results of studying the relationship between the bioelectrical activity of the brain, neuroenergetic exchange, the state of extracranial vessels, cognitive functions, in case of vibration disease caused by the effect of combined local and general vibration (CLGV) are presented.

Materials and methods. Constant potential levels (CPP), characteristics of somatosensory evoked potentials (SSEPs), doppler ultrasound (USDG) and electroencephalography (EEG), neuropsychological features were studied in thirty eight patients exposed to CLGV, 32 persons of the comparison group.

Results. Under CLGV topical disorganization and inhibition of alpha and beta activity, an increase in pathological delta activity, in the level of constant potential (DC-potential level) in the left frontal, right temporal and posterior parts of the brain, an increase in the latency of the N13, N20 components, the duration of the N18-N20 interval are associated with an increase in the tone of the main extracranial arteries, a decrease in associative-logical thinking, short-term and long-term memory, dynamic praxis, and reciprocal coordination. Indicators of impaired neurofunctional activity (NFA) are an increase in the linear blood flow velocity (LBFV) in the internal carotid artery (ICA), the circulatory resistance index of the ICA, the DC-potential level of the occipital, central right, and parietal left leads; decrease in indices of theta — rhythm in the anterofrontal and parietal right, occipital left leads, indices of beta1, beta2 — rhythms in the occipital left lead.

Limitations. The limitations of the work are presented in the form of a small number of individuals in groups, insufficient depth of the study of foreign literature materials on the issue under study.

Conclusion. The interdependence of indicators characterizing the decrease in the tone of the cerebral cortex, cognitive functions, the state of the hypothalamic-stem connections, the increase in the tone of the extracranial arteries, as well as diagnostic signs that make it possible to detect changes in NFA in CLGV.

Compliance with ethical standards. Examination of patients was carried out in accordance with the ethical standard of the Declaration of Helsinki of the world association “Ethical principles for conducting scientific medical research involving humans”, as amended in 2000. and “Rules of Clinical Practice in the Russian Federation”, approved by the Order of the Ministry of Health of the Russian Federation No. 266 dated 06/19/2003. All examined signed an informed consent to participate in the study and there is a conclusion of the local ethical committee (LEK) (protocol No. 5 dated 11/14/2012).

Contribution:
Shevchenko O.I. — the concept and design of the study, developed a study plan, formed a common base, collected and analyzed data on NEC, neuropsychological examination, wrote and designed an article, formulated conclusions;
Lakhman O.L. — took part in the formation of the concept of the study, took part in editing the article;
Katamanova E.V. — collected data on EEG and ultrasound;
Pyatkov Yu.S. — collected data on ultrasound;
Rusanova D.V. — collected data;
Kodinets I.N. — contributed to the organization of research, data processing on ultrasound.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version. 

Conflict of interest. The authors declare no conflict of interest. 

Acknowledgement. The study had no sponsorship. 

Received: June 20, 2022 / Accepted: October 3, 2022 / Published: November 30, 2022