Methodical support for controlling safety of cereals for children (exemplified by furan and methylfuran)
- Authors: Zaitseva N.V.1, Nurislamova T.V.1, Maltseva O.A.1, Chinko T.V.1, Subbotina D.Y.1
-
Affiliations:
- Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing
- Issue: Vol 102, No 7 (2023)
- Pages: 713-719
- Section: METHODS OF HYGIENIC AND EXPERIMENTAL INVESTIGATIONS
- Published: 31.08.2023
- URL: https://rjraap.com/0016-9900/article/view/638524
- DOI: https://doi.org/10.47470/0016-9900-2023-102-7-713-719
- EDN: https://elibrary.ru/mtwcnm
- ID: 638524
Cite item
Full Text
Abstract
Introduction. The study addresses issues related to developing a procedure for identification of chemicals in food products in practical instrumental investigations. We have validated the method for quantification of a heterocyclic compound (furan) and sylvan (methylfuran) in grain-based cereals for children.
The aim of this study was to develop a precise GC-MS-method for quantifying a heterocyclic compound and sylvan in food products to control their safety for children, especially infants.
Materials and methods. The research objects were quantification means (QM) as a certain amount of an analyzed heterocyclic compound and sylvan (the mass share of the analyzed compound is 99%) provided by Sigma Aldrich Corporation (USA), as well as milk and milk-free dry cereals for babies. The study involved using an Agilent 7890А gas chromatographer with 5975С quadrupole mass-spectrometric detector. Sample preparation involved extraction and concentration of furan and methylfuran from food samples by statistical vapour-liquid equilibrium analysis and subsequent gas-chromatographic analysis of vapour phase.
Results. The procedure for quantification of furan and methylfuran is an original scientific and technical development based on experimental data. It gives an opportunity to identify furan and methylfuran micro-admixtures in food samples with high precision and sensitivity with a range of concentrations between 0.93 and 9.37 ng and between 0.91 and 9.13 ng accordingly. The ultimate indicators describing acceptability of the results obtained by furan and methylfuran quantification included error not higher than 24%, пintra-laboratory precision (σRл) not higher than 10%, correctness (± σCл) not higher than 22%.
Conclusion. The developed technique has shown high selectivity, sensitivity, reliability and satisfactory accuracy. The methodology meets the criteria of the State Standard of the Russian Federation GOST R ISO 5725-1-6-2002 and can be used for laboratory studies of food safety by enterprises and institutions engaged in quality control and research of food products and food raw materials.
Contribution:
Zaitseva N.V. — topicality, conclusion;
Nurislamova Т.V. — topicality, conclusion;
Maltseva О.А. — topicality, results, discussion, conclusion;
Chinko Т.V. — materials and methods, results;
Subbotina D.Yu. — analytical and experimental research.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.
Conflict of interest. The authors declare no conflict of interest.
Acknowledgement. The study had no sponsorship.
Received: May 22, 2023 / Accepted: June 7, 2023 / Published: August 30, 2023
About the authors
Nina V. Zaitseva
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing
Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0003-2356-1145
Russian Federation
Tatyana V. Nurislamova
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing
Email: nurtat@fcrisk.ru
ORCID iD: 0000-0002-2344-3037
Doctor of Biological Sciences, head of the Gas Chromatography Laboratory of the Department of Analytical Chemistry Analysis, the Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, 614045, Russian Federation.
e-mail: nurtat@fcrisk.ru
Russian FederationOlga A. Maltseva
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing
Email: noemail@neicon.ru
ORCID iD: 0000-0001-7664-3270
Russian Federation
Tatyana V. Chinko
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing
Email: noemail@neicon.ru
ORCID iD: 0000-0001-5669-1689
Russian Federation
Daria Yu. Subbotina
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies of the Federal Service for Surveillance over Consumer Rights Protection and Human Wellbeing
Email: noemail@neicon.ru
ORCID iD: 0000-0003-3030-3275
Russian Federation
References
- Doronin A.F., Pavlova T.V. Balakhanov M.V., Davydov E.V., Dobrovol’skiy V.I., Leskov A.S., et al. Ensuring of food safety control – one of the most important tasks of the food industry. Pishchevaya promyshlennost’. 2013; (5): 14–7. https://elibrary.ru/qjcrsr (in Russian)
- FDA. Guidance Document: Fumonisin levels in human foods and animal feeds; 2001. Available at: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/guidance-industry-fumonisin-levels-human-foods-and-animal-feeds
- Khotimchenko S.A., Gmoshinskiy I.V., Bagryantseva O.V., Shatrov G.N. Chemical food safety: development of methodological and regulatory base. Voprosy pitaniya. 2020; 89(4): 110–24. https://doi.org/10.24411/0042-8833-2020-10047 https://elibrary.ru/aywxum (in Russian)
- Chizhov A.Ya. Modern Problems of Human Ecological Pathology [Sovremennye problemy ekologicheskoy patologii cheloveka]. Moscow; 2008. (in Russian)
- IARC Monographs on the Evaluation of Carcinogenic Risks for Humans. Supplement 7, Vol. 1–42. Lyon; 1987.
- Russo M.T., De Luca G., Palma N., Leopardi P., Degan P., Cinelli S., et al. Oxidative stress, mutations and chromosomal aberrations induced by in vitro and in vivo exposure to Furan. Int. J. Mol. Sci. 2021; 22(18): 9687. https://doi.org/10.3390/ijms22189687
- Byrns M.C., Vu C.C., Neidigh J.W., Abad J.L., Jones R.A., Peterson L.A. Detection of DNA adducts derived from the reactive metabolite of furan, cis-2-butene-1,4-dial. Chem. Res. Toxicol. 2006; 19(3): 414–20. https://doi.org/10.1016/10.1021/tx050302k
- Food Contaminants legislation. Premier Analytical Services; 2021. Available at: https://www.paslabs.co.uk/wp-content/uploads/2021/09/Contaminants-legislation-diverges-and-impacts-foods-safety-testing-Sept-21.pdf
- Holscher W., Steinhart H. Investigation of roasted coffee freshness with an improved headspace technique. Z. Lebensm. Unters. Forch. 1992; 195: 33–8. https://doi.org/10.1007/BF01197836
- Zoller O., Sager F., Reinhard H. Furan in food: headspace method and product survey. Food Addit. Contam. 2007; 24(Suppl. 1): 91–107. https://doi.org/10.1080/02652030701447389
- Javed F., Shahbaz H.M., Nawaz A., Olaimat A.N., Stratakos A.C., Wahyono A., et al. Formation of furan in baby food products: Identification and technical challenges. Compr. Rev. Food Sci. Food Saf. 2021; 20(3): 2699–715. https://doi.org/10.1111/1541-4337.12732
- Vitenberg A.G. Equilibrium model in describing the processes of gas extraction and headspace analysis. Zhurnal analiticheskoy khimii. 2003; 58(1): 2–15. https://doi.org/10.1023/A:1021873828994 https://elibrary.ru/lhzomp
- Crews C., Castle L. A review of the occurrence, formation and analysis of furan in heat processed foods. Trends Food Sci. Technol. 2007; 18(7): 365–72. https://doi.org/10.1016/j.tifs.2007.03.006
- Kim Y.J., Choi J., Lee G., Lee K.G. Analysis of furan and monosaccharides in various coffee beans. Trends Food Sci. Technol. 2021; 58(3): 862–9. https://doi.org/10.1007/s13197-020-04600-5
- Lebedev A.T. Mass Spectrometry in Organic Chemistry [Mass-spektrometriya v organicheskoy khimii]. Moscow: Binom. Laboratoriya znaniy; 2003. (in Russian)
- Budnikov G.K. Determination of trace amounts of substances as a problem of modern analytical chemistry. Sorosovskiy obrazovatel’nyy zhurnal. 2000; 6(3): 45–51. (in Russian)
- Vitol I.S. Ecological Problems of Food Production and Consumption [Ekologicheski problemy proizvodstva i potrebleniya pishchevykh produktov]. Moscow; 2000. https://elibrary.ru/vhjlhj (in Russian)
- Larson P., Newton B. HP Technical Paper. 1986; 115: Publication 43-5954-7555.
- Zhukhovitskiy A.A., Revel’skiy I.A., Yanovskiy S.M. Chromodistillation and Chromatography [Khromadistillyatsiya i khromatografiya]. Moscow: Tekhnosfera; 2021. https://elibrary.ru/piagfj (in Russian)
- Food and Drug Administration (FDA). In: Vohr H.W., ed. Encyclopedia of Immunotoxicology. Berlin, Heidelberg: Springer; 2016. https://doi.org/10.1007/978-3-642-54596-2_200584
Supplementary files
