Biological effects of oxygen-enriched drinking water. Review. Part 1.

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Abstract

Human life on Earth depends on the continuous availability of oxygen, but conditions for the entry of oxygen into the cells of the body change in time and space, easily broken, owing to what may develop hypoxia - a condition of oxygen starvation of tissues. The first part of the review provides information on the maintenance of oxygen homeostasis in cells, on the key component responsible for the regulation of the molecular response to hypoxia - the HIFs family of transcription factors (Hypoxia-Inducible Factors). It is indicated that it is possible to compensate for the lack of oxygen in the body by delivering it to cells and tissues with water and various oxygen cocktails. Data from experimental studies of the biological effect of oxygenated drinking water, as well as the results of studying the effects of oxygen-enriched drinking water with the participation of volunteers are presented. The issue of the formation of oxygen (free) radicals when drinking oxygen-enriched drinking water is considered. The second part of the review will provide data on the successful use of oxygen-rich water in domestic therapeutic and surgical practice in complex treatment in order to reduce the negative effect of hypoxia in patients with chronic heart failure and generalized peritonitis complicated by intestinal insufficiency syndrome; on the method of improving the supply of oxygen to the body using enteral oxygen therapy - oxygen cocktails - for diseases of the heart, lungs, bronchi and gastrointestinal tract, atopic dermatitis, placental insufficiency, as well as to improve physical and mental performance. The review draws specialist’s attention to the problem of the biological effect of oxygen-enriched drinking water, its insufficient knowledge and the possible yet unrealized potential in terms of preventing various diseases and maintaining optimal human health.

About the authors

Jurii A. Rakhmanin

Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency

Author for correspondence.
Email: noemail@neicon.ru
ORCID iD: 0000-0003-2067-8014
Russian Federation

Natalija A. Egorova

Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency

Email: tussy@list.ru
ORCID iD: 0000-0001-6751-6149

MD., Ph.D., DSci., leading researcher of the Environmental health department of the A.N.Sysin Research Institute of Human Ecology and Environmental Health of the Centre for Strategic Planning and Management of Biomedical Health Risks (Centre for Strategic Planning), Moscow, 119121, Russian Federation.

e-mail: tussy@list.ru

Russian Federation

Rufina I. Mihaylova

Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency

Email: noemail@neicon.ru
ORCID iD: 0000-0001-7194-9131
Russian Federation

Irina N. Ryzhova

Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency

Email: noemail@neicon.ru
ORCID iD: 0000-0003-0696-5359
Russian Federation

Marina G. Kochetkova

Centre for Strategic Planning and Management of Biomedical Health Risks of the Federal Medical Biological Agency

Email: noemail@neicon.ru
ORCID iD: 0000-0001-9616-4517
Russian Federation

References

  1. Handbook of chemists 21. Chemistry and chemical technology. Oxygen. Available at: https://www.chem21.info/info/1286860/ (in Russian)
  2. Big Medical Encyclopedia; 1970. Oxygen. Available at: http://med.niv.ru/doc/encyclopedia/med/articles/1316/kislorod.htm (in Russian)
  3. Griffioen A.W., Bischoff J. Oxygen sensing decoded: A Nobel concept in biology. Angiogenesis. 2019; 22(4): 471–2. https://doi.org/10.1007/s10456-019-09692-y
  4. Litvitskiy P.F. Hypoxia. Voprosy sovremennoy pediatrii. 2016; 15(1): 45–54. https://doi.org/10.15690/vsp.v15i1.1499 (in Russian)
  5. Zarubina I.V. Modern view on pathogenesis of hypoxia and its pharmacological correction. Obzory po klinicheskoy farmakologii i lekarstvennoy terapii. 2011; 9(3): 31–48. (in Russian)
  6. Petrov V.N. Features of influence of oxygen’ partial density gradient in the air on the health status of populations living in the Arctic zone of the Russian Federation. estnik Kol’skogo nauchnogo tsentra Rossiyskoy akademii nauk. 2015; (3): 82–92. (in Russian)
  7. Filippov M.M., Balykin M.V., Il’in V.N., Portnichenko V.I., Evtushenko A.L. Comparative characteristic of hypoxia exersize, developing at muscle activity, and hypoxic hypoxia in mountains. Ul’yanovskiy mediko-biologicheskiy zhurnal. 2014; (4): 86–94. (in Russian)
  8. Divert V.E., Komlyagina T.G., Krasnikova N.V., Martynov A.B., Timofeev S.I., Krivoshchekov S.G. Cardiorespiratory responses of swimmers to hypoxia and hypercapnia. Vestnik Novosibirskogo gosudarstvennogo pedagogicheskogo universiteta. 2017; 7(5): 207–24. https://doi.org/10.15293/2226-3365.1705.14 (in Russian)
  9. Dzhalilova D.Sh., Makarova O.V. Molecular-biological mechanisms of interconnection between hypoxia, inflammatory and immune reactions. Immunologiya. 2019; 40(5): 97–105. https://doi.org/10.24411/0206-49522019-15010 (in Russian)
  10. Novikov V.E., Levchenkova O.S. Hypoxia-inducible factor as a pharmacological target. Obzory po klinicheskoy farmakologii i lekarstvennoy terapii. 2013; 11(2): 8–16. (in Russian)
  11. Borovik T.E., Semenova N.N., Davydova E.V., Dublina E.S., Roslavtseva E.A., Pisareva I.V., et al. Efficiency of oxygen cocktails during the respiratory and digestive diseases among children. Voprosy sovremennoy pediatrii. 2007; 6(2): 97–101. (in Russian)
  12. Zhang Q., Yan Q., Yang H., Wei W. Oxygen sensing and adaptability won the 2019 Nobel prize in physiology or medicine. Genes Dis. 2019; 6(4): 328–32. https://doi.org/10.1016/j.gendis.2019.10.006
  13. Kaelin W.G., Ratcliffe P.J., Semenza G.L. Pathways for oxygen regulation and homeostasis: The 2016 Albert Lasker basic medical research award. JAMA. 2016; 316(12): 1252–3. https://doi.org/10.1001/jama.2016.12386
  14. Akalaev R.N., Borisova E.M., Evdokimov E.A., Romasenko M.V., Levina O.A., Mitrokhin A.A., et al. Hyperbaric medicine: the history of formation and path of development. Vestnik ekstrennoy meditsiny. 2014; (1): 85–94. (in Russian)
  15. Akalaev R.N., Savilov P.N., Sharipova V.Kh., Stopnitskiy A.A., Rosstal’naya A.L. Disputable questions of hyperbaric medicine. Vestnik ekstrennoy meditsiny. 2014; (4): 84–7. (in Russian)
  16. Shin D., Cho E.S., Bang H.T., Shim K.S. Effects of oxygenated or hydrogenated water on growth performance, blood parameters, and antioxidant enzyme activity of broiler chickens. Poult. Sci. 2016; 95(11): 2679–84. https://doi.org/10.3382/ps/pew237
  17. Gruber R., Axmann S., Schoenberg M.H. The influence of oxygenated water on the immune status, liver enzymes, and the generation of oxygen radicals: a prospective, randomised, blinded clinical study. Clin. Nutr. 2005; 24(3): 407–14. https://doi.org/10.1016/j.clnu.2004.12.007
  18. Wing S.L., Askew E.W., Luetkemeier M.J., Ryujin D.T., Kamimori G.H., Grissom C.K. Lack of effect of rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Environ. Med. 2003; 14(1): 9–16. https://doi.org/10.1580/1080-6032(2003)014%5B0009:loeoro%5D2.0.co;2
  19. Forth W., Adam O. Uptake of oxygen from the intestine – experiments with rabbits. Eur. J. Med. Res. 2001; 6(11): 488–92.
  20. Sommer A.M., Bogusch C., Lerchl A. Cognitive function in outbred house mice after 22 weeks of drinking oxygenated water. Physiol. Behav. 2007; 91(1): 173–9. https://doi.org/10.1016/j.physbeh.2007.02.007
  21. Fang C.H., Tsai C.C., Shyong Y.J., Yang C.T., Li K.Y., Lin Y.W., et al. Effects of highly oxygenated water in a hyperuricemia rat model. J. Healthc. Eng. 2020; 2020: 1323270. https://doi.org/10.1155/2020/1323270
  22. Jung B.G., Lee J.A., Nam K.W., Lee B.J. Oxygenated drinking water enhances immune activity in broiler chicks and increases survivability against Salmonella Gallinarum in experimentally infected broiler chicks. J. Vet. Med. Sci. 2012; 74(3): 341–6. https://doi.org/10.1292/jvms.11-0316
  23. Jung B.G., Lee J.A., Lee B.J. Oxygenated drinking water enhances immune activity in pigs and increases immune responses of pigs during Salmonella Typhimurium infection. J. Vet. Med. Sci. 2012; 74(12): 1651–5. https://doi.org/10.1292/jvms.11-0316
  24. Charton A., Péronnet F., Doutreleau S., Lonsdorfer E., Klein A., Jimenez L., et al. Effect of administration of water enriched in O2 by injection or electrolysis on transcutaneous oxygen pressure in anesthetized pigs. Drug Des. Devel. Ther. 2014; 8: 1161–7. https://doi.org/10.2147/DDDT.S66236
  25. Zoll J., Bouitbir J., Sirvent P., Klein A., Charton A., Jimenez L., et al. Apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection. Drug Des. Devel. Ther. 2015; 9: 3589–97. https://doi.org/10.2147/DDDT.S81891
  26. Reading S.A., Yeomans M., Levesque C. Skin oxygen tension is improved by immersion in oxygen-enriched water. Int. J. Cosmet. Sci. 2013; 35(6): 600–7. https://doi.org/10.1111/ics.12083
  27. Wing-Gaia S.L., Subudhi A.W., Askew E.W. Effects of purified oxygenated water on exercise performance during acute hypoxic exposure. Int. J. Sport. Nutr. Exerc. Metab. 2005; 15(6): 680–8. https://doi.org/10.1123/ijsnem.15.6.680
  28. Hampson N.B., Pollock N.W., Piantadosi C.A. Oxygenated water and athletic performance. JAMA. 2003; 290(18): 2408–9. https://doi.org/10.1001/jama.290.18.2408-c
  29. Leibetseder V., Strauss-Blasche G., Marktl W., Ekmekcioglu C. Does oxygenated water support aerobic performance and lactate kinetics? Int. J. Sports Med. 2006; 27(3): 232–5. https://doi.org/10.1055/s-2005-865633
  30. Schoenberg M.H., Hierl T.C., Zhao J., Wohlgemuth N., Nilsson U.A. The generation of oxygen radicals after drinking of oxygenated water. Eur. J. Med. Res. 2002; 7(3): 109–16.
  31. Pietri S., Séguin J.R., D’Arbigny P., Culcasi M. Ascorbyl free radical: A noninvasive marker of oxidative stress in human open-heart surgery. Free Radic. Biol. Med. 1994; 16(4): 523–8. https://doi.org/10.1016/0891-5849(94)90131-7
  32. Duan S., Gu L., Wang Y., Zheng R., Lu J., Yin J., et al. Regulation of influenza virus-caused oxidative stress by Kegan Liyan oral prescription, as monitored by ascorbyl radical ESR signals. Am. J. Chin. Med. 2009; 37(6): 1167–77. https://doi.org/10.1142/S0192415X09007570

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Copyright (c) 2024 Rakhmanin J.A., Egorova N.A., Mihaylova R.I., Ryzhova I.N., Kochetkova M.G.


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