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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Regional Anesthesia and Acute Pain Management</journal-id><journal-title-group><journal-title xml:lang="en">Regional Anesthesia and Acute Pain Management</journal-title><trans-title-group xml:lang="ru"><trans-title>Регионарная анестезия и лечение острой боли</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1993-6508</issn><issn publication-format="electronic">2687-1394</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">630868</article-id><article-id pub-id-type="doi">10.17816/RA630868</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Application of cryoanalgesia for accelerated rehabilitation after total knee arthroplasty: review</article-title><trans-title-group xml:lang="ru"><trans-title>Применение криоаналгезии для ускоренной реабилитации после эндопротезирования коленного сустава: обзор литературы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0405-4888</contrib-id><contrib-id contrib-id-type="spin">7268-3350</contrib-id><name-alternatives><name xml:lang="en"><surname>Pinchuk</surname><given-names>Nikita E.</given-names></name><name xml:lang="ru"><surname>Пинчук</surname><given-names>Никита Евгеньевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>nikitapinchuk78@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1437-7162</contrib-id><contrib-id contrib-id-type="spin">9270-6158</contrib-id><name-alternatives><name xml:lang="en"><surname>Ushakov</surname><given-names>Alexey A.</given-names></name><name xml:lang="ru"><surname>Ушаков</surname><given-names>Алексей Андреевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>smushakov@gmail.com</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2386-9281</contrib-id><contrib-id contrib-id-type="spin">8850-2071</contrib-id><name-alternatives><name xml:lang="en"><surname>Antipin</surname><given-names>Eduard E.</given-names></name><name xml:lang="ru"><surname>Антипин</surname><given-names>Эдуард Эдуардович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), associate professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, доцент</p></bio><email>vard67@mail.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1267-9781</contrib-id><contrib-id contrib-id-type="spin">2074-3953</contrib-id><name-alternatives><name xml:lang="en"><surname>Yakovenko</surname><given-names>Maxim P.</given-names></name><name xml:lang="ru"><surname>Яковенко</surname><given-names>Максим Петрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>alter83@mail.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Krasnoyarsk Interdistrict Clinical Hospital of Emergency Medical Care named after N.S. Karpovich</institution></aff><aff><institution xml:lang="ru">Красноярская межрайонная клиническая больница скорой медицинской помощи им. Н.С. Карповича</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Northern State Medical University</institution></aff><aff><institution xml:lang="ru">Северный государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Federal Research Centre «Kola Science Centre of the Russian Academy of Sciences»</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский центр медико-биологических проблем адаптации человека в Арктике Кольского научного центра РАН</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Pain Management and Rehabilitation Center «Anesta»</institution></aff><aff><institution xml:lang="ru">Многопрофильный центр лечения боли и реабилитации «Анеста»</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Pain Treatment Clinic</institution></aff><aff><institution xml:lang="ru">Клиника лечения боли</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2024-10-10" publication-format="electronic"><day>10</day><month>10</month><year>2024</year></pub-date><pub-date date-type="pub" iso-8601-date="2024-12-21" publication-format="electronic"><day>21</day><month>12</month><year>2024</year></pub-date><volume>18</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>245</fpage><lpage>260</lpage><history><date date-type="received" iso-8601-date="2024-04-24"><day>24</day><month>04</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-09-22"><day>22</day><month>09</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Эко-Вектор</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder></permissions><self-uri xlink:href="https://rjraap.com/1993-6508/article/view/630868">https://rjraap.com/1993-6508/article/view/630868</self-uri><abstract xml:lang="en"><p>Cryoanalgesia is a modern and increasingly popular technique for managing acute and chronic pain. It involves the percutaneous insertion of a cryoprobe at extremely low temperatures to disrupt nerve function. This review attempts to summarize and evaluate the existing evidence on the benefits and safety of cryoneurolysis as a method of perioperative analgesia in total knee arthroplasty (TKA), with a focus on its role in accelerating patient rehabilitation.</p> <p>The authors conducted a literature search across databases including PubMed (MEDLINE), eLibrary.Ru, Google Scholar, Springer Library, Cochrane Library, and Wiley Online Library, covering the period from 2014 to 2024. Fifteen articles on the use of cryoanalgesia in TKA were identified and analyzed. The data obtained were summarized and interpreted. The analysis indicated that cryoanalgesia is a promising approach for prolonged perioperative pain control as part of a multimodal analgesia strategy. A clinically significant advantage of cryoneurolysis may be the early rehabilitation of patients after surgery. However, the significant risk of systematic bias and clinical heterogeneity in the existing literature precludes a reliable quantitative assessment of any efficacy measures. Future studies should ensure transparent and unbiased reporting of treatment parameters and outcomes to improve scientific reproducibility.</p></abstract><trans-abstract xml:lang="ru"><p>Криоаналгезия — современная и набирающая популярность методика лечения острой и хронической боли. Данный метод включает чрескожное введение криозонда, подвергаемого воздействию чрезвычайно низких температур, чтобы нарушить нервы. Данный обзор представляет собой попытку обобщить и оценить имеющиеся данные о пользе и безопасности крионевролиза как метода периоперационной аналгезии при тотальном эндопротезировании коленного сустава (ТЭКС), ответить на вопрос, действительно ли периоперационное применение криоаналгезии способствует ускоренной реабилитации пациентов после ТЭКС. Авторами был проведён поиск публикаций в базах данных PubMed (Medline), eLibrary.Ru, Google Scholar, Springer Library, Cochrane Library, Wiley Online Library за период с 2014 по 2024 год, найдено и проанализировано 15 статей, посвящённых применению криоаналгезии при ТЭКС. Полученные данные были обобщены и интерпретированы. По итогам анализа авторы обзора пришли к выводу, что криоаналгезия является перспективным методом обеспечения длительного периоперационного контроля боли в составе схем мультимодальной аналгезии. Клинически значимым показателем в пользу крионевролиза может стать ранняя реабилитация пациента после оперативного вмешательства. Однако значительный риск систематической ошибки и клинической гетерогенности существующей литературы, изучающей данную проблему, исключает возможность надёжной количественной оценки любых показателей эффективности, представленных в ней. Будущие исследования должны обеспечить прозрачную, непредвзятую отчётность о параметрах лечения и результатах для улучшения научной воспроизводимости.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cryoneurolysis</kwd><kwd>cryoanalgesia</kwd><kwd>knee joint</kwd><kwd>pain</kwd><kwd>total knee arthroplasty</kwd><kwd>arthroplasty</kwd><kwd>multimodal analgesia</kwd><kwd>perioperative</kwd><kwd>preventive</kwd><kwd>opioid</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>крионевролиз</kwd><kwd>криоаналгезия</kwd><kwd>коленный сустав</kwd><kwd>боль</kwd><kwd>тотальное эндопротезирование</kwd><kwd>артропластика</kwd><kwd>мультимодальная аналгезия</kwd><kwd>периоперационный</kwd><kwd>превентивный</kwd><kwd>опиоид</kwd></kwd-group><funding-group><award-group><funding-source><institution-wrap><institution xml:lang="ru">Министерство науки и высшего образования Российской Федерации</institution></institution-wrap><institution-wrap><institution xml:lang="en">Ministry of Science and Higher Education of the Russian Federation</institution></institution-wrap></funding-source><award-id>122022200516-5</award-id></award-group></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Patel A, Pavlou G, Mújica-Mota RE, Toms AD. 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