Regional Anesthesia and Acute Pain ManagementRegional Anesthesia and Acute Pain ManagementРегионарная анестезия и лечение острой боли1993-65082687-1394Eco-Vector62400310.17816/RA624003ReviewsНаучные обзорыReview ArticleHistory and prospects for the use of morphine in clinical practice: literature reviewИстория и перспективы применения морфина в клинической практике: обзор литературыhttps://orcid.org/0000-0001-5550-1628572231830486793-7478RaspopinYurii S.РаспопинЮрий Святославович
Russian Federation

MD, Cand. Sci. (Medicine)

канд. мед. наук

oar24@mail.ruhttps://orcid.org/0000-0002-6113-84986507655298AAY-3981-20204582-8494ShifmanEfim M.ШифманЕфим Муневич
Russian Federation

MD, Dr. Sci. (Medicine), professor

д-р мед. наук, профессор

eshifman@mail.ruhttps://orcid.org/0000-0002-3901-2696FeoktistovaDaria A.ФеоктистоваДарья Александровна
Russian Federation

student

студентка

keniw2014@yandex.ruVoino-Yasenetsky Krasnoyarsk State Medical UniversityКрасноярский государственный медицинский университет им. проф. В.Ф. Войно-ЯсенецкогоKrasnoyarsk Regional Clinical Center Krasnoyarsk of Maternal and Child HealthКраевой клинический центр охраны материнства и детстваVladimirsky Moscow Regional Research Clinical InstituteМосковский областной научно-исследовательский клинический институт им. М.Ф. ВладимирскогоPirogov Russian National Research Medical UniversityРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова290220242603202418133402811202331012024Copyright ©; 2024, Eco-VectorCopyright ©; 2024, Эко-Вектор2024Eco-VectorЭко-Векторhttps://creativecommons.org/licenses/by-nc-nd/4.0/https://rjraap.com/1993-6508/article/view/624003

The authors analyzed various studies on acute and chronic pain syndrome treatment. This review provides brief historical data on the discovery and use of morphine from ancient times to present. Morphine remains one of the most common painkillers worldwide and has a rich history dating back more than 200 years. Its basic properties, pharmacokinetics, pharmacodynamics, and principles of use are discussed. No drug has had such an impact on society as morphine because of its medical use as a pain reliever and its illicit use as a drug of addiction and abuse. This review includes the main modern recommendations for the treatment of acute and chronic pain, particularly from the World Health Organization for the treatment of chronic pain and the Procedure-Specific Postoperative Pain Management (PROSPECT) group for the treatment of postoperative pain in various surgical interventions. The types of opioids and their clinical use are described, and the authors’ opinion on the current use of morphine for treating acute and chronic pain syndrome is presented.

Проанализированы различные материалы по лечению острого и хронического болевого синдрома. В обзоре представлены краткие исторические данные открытия и использования морфина начиная с древних времен и до настоящих дней. Морфин остаётся одним из самых распространённых обезболивающих средств в мире, имеет богатейшую историю, насчитывающую более 200 лет. Освещены основные свойства препарата, его фармакокинетика и фармакодинамика, принципы применения. Ни один препарат не оказывал такого влияния на общество, как морфин, благодаря его медицинскому применению в качестве обезболивающего препарата, а также по причине незаконного употребления в качестве наркотического средства, вызывающего привыкание и злоупотребление. В обзор включены основные современные рекомендации по лечению острой и хронической боли, в частности рекомендации Всемирной организации здравоохранения по лечению хронической боли и группы PROSPECT (Procedure-Specific Postoperative Pain Management) по лечению послеоперационной боли при различных оперативных вмешательствах. Описаны виды опиоидов и их клиническое применение, озвучено мнение авторов о современном месте морфина в лечении острого и хронического болевого синдрома.

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