Regional Anesthesia and Acute Pain ManagementRegional Anesthesia and Acute Pain ManagementРегионарная анестезия и лечение острой боли1993-65082687-1394Eco-Vector5765910.17816/RA57659ReviewsНаучные обзорыReview ArticleAnimal models of chronic pain. In vivo experimentsМоделирование хронического болевого синдрома в эксперименте на животныхhttps://orcid.org/0000-0002-3162-6298KhinovkerV. V.ХиновкерВ. В.
Russian Federation

к. мед. н., заведующий отделением анестезиологии и реанимации

vhinov@hotmail.comhttps://orcid.org/0000-0002-8860-9480KhinovkerE. V.ХиновкерЕ. В.
Russian Federation
vhinov@hotmail.comFederal Siberian Research Clinical Centre FMBA of RussiaФГБУ «Федеральный Сибирский научно-клинический центр» ФМБА РоссииKrasnoyarsk State Medical University named after Prof. V.F. Voino-YasenetskyФГБОУ ВО «КрасГМУ им. проф. В.Ф. Войно-Ясенецкого» Министерства здравоохранения Российской Федерации071220201431211290701202107012021Copyright ©; 2020, Eco-VectorCopyright ©; 2020, ООО "Эко-Вектор"2020Eco-VectorООО "Эко-Вектор"https://rjraap.com/1993-6508/article/view/57659

As a result of population aging and increasing of comorbide patients procent, chronic pain nowadays is the one of the most important medical problems and its treatment becoming one of progressive and popular researching topics. First part of acute or chronic pain research is a model that meets the specified criteria. First model of cronic pain – sciatic nerve damaging was founded and proven more than 30 years ago. Nowadays there is a lot of in vivo and in vitro models that matched with different pathologies and also mechanisms of chronic nociceptive and neuropathic pain on different levels have been learned. In this article we review the most effective and often used rat models of chronic pain its mechanisms and assessment methods. The information based on the most citated articles for 10 years.

Вследствие старения населения и увеличения процента коморбидных пациентов хроническая боль становится одной из важнейших медицинских проблем, а еë лечение – одним из наиболее популярных исследовательских направлений. Первичным этапом в изучении как острой, так и хронической боли являются различные лабораторные модели, каждая из которых отвечает заданным для исследования критериям. Первая модель хронической боли на животных – частичное пересечение седалищного нерва у крыс, была описана и доказана более 30 лет назад. На данный момент существует ряд моделей in vivo и in vitro, отвечающих различным вариантам патологий, а также изучены механизмы хронической невропатической и ноцицептивной боли на различных уровнях. В данной статье на основе анализа часто цитируемых статей по лечению и изучению хронической боли за последние 10 лет мы рассматриваем наиболее эффективные и используемые модели на крысах, способы их воспроизведения и оценки.

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