<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Regional Anesthesia and Acute Pain Management</journal-id><journal-title-group><journal-title xml:lang="en">Regional Anesthesia and Acute Pain Management</journal-title><trans-title-group xml:lang="ru"><trans-title>Регионарная анестезия и лечение острой боли</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1993-6508</issn><issn publication-format="electronic">2687-1394</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">57658</article-id><article-id pub-id-type="doi">10.17816/RA57658</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorials</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Редакционные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Propofol and postoperative pain. Time to change priorities?</article-title><trans-title-group xml:lang="ru"><trans-title>Пропофол и послеоперационная боль. Время менять приоритеты?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3453-8699</contrib-id><name-alternatives><name xml:lang="en"><surname>Ovechkin</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Овечкин</surname><given-names>А. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д. мед. н., профессор кафедры анестезиологии и реаниматологии</p></bio><email>ovechkin_alexei@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый московский государственный медицинский университет им. И.М. Сеченова» (Сеченовский университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-12-07" publication-format="electronic"><day>07</day><month>12</month><year>2020</year></pub-date><volume>14</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>118</fpage><lpage>120</lpage><history><date date-type="received" iso-8601-date="2021-01-07"><day>07</day><month>01</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-01-07"><day>07</day><month>01</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ООО "Эко-Вектор"</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder></permissions><self-uri xlink:href="https://rjraap.com/1993-6508/article/view/57658">https://rjraap.com/1993-6508/article/view/57658</self-uri><abstract xml:lang="en"><p>Currently, the use of inhalational anesthetics is the basic method of general anesthesia. Propofol-based total intravenous anesthesia (TIVA) is not widely used. However, over the past years, evidence-based medicine data have been obtained on a decrease in the intensity of postoperative pain and the need for analgesics in patients operated on under the conditions of propofol-based TIVA, compared with inhalation anesthesia. It is possible that this fact will form the basis for revising general anesthesia regimens.</p></abstract><trans-abstract xml:lang="ru"><p>В настоящее время применение ингаляционных анестетиков является базовым методом общей анестезии. Тотальная внутривенная анестезия (ТВА) на основе пропофола мало распространена. Однако на протяжении последних лет получены данные доказательной медицины о снижении интенсивности послеоперационной боли и потребности в анальгетиках у пациентов, оперированных в условиях ТВА на основе пропофола, по сравнению с ингаляционной анестезией. Возможно, что этот факт явится основой для пересмотра схем общей анестезии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>propofol</kwd><kwd>inhalational anesthetics</kwd><kwd>postoperative pain</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>пропофол</kwd><kwd>ингаляционные анестетики</kwd><kwd>послеоперационная боль</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Chan A, Qiu Q, Choi S, Wong SS, Chan ACY, Irwin MG et al. Effects of intra-operative total intravenous anaesthesia with propofol versus inhalational anaesthesia with sevoflurane on post-operative pain in liver surgery: a retrospective case-control study. PLoS One. 2016;11(2): e0149753. DOI: https://doi.org/10.1371/journal.pone.0149753.</mixed-citation><mixed-citation xml:lang="ru">Chan A., Qiu Q., Choi S.W., Wong S.S.C.,Chan A.C.Y.,Irwin M.G. et al. Effects of intra-operative total intravenous anaesthesia with propofol versus inhalational anaesthesia with sevoflurane on post-operative pain in liver surgery: a retrospective case-control study // PLoS One. 2016. Vol. 11. N 2. e0149753. DOI: https://doi.org/10.1371/journal.pone.0149753.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Ogurlu M, Sari S, Kucuk M, Bakis M, Uguir B, Eshraghi YE et al. Comparison of the effect of propofol and sevoflurane anaesthesia on acute and chronic postoperative pain after hysterectomy. Anaesth Intensive Care. 2014;42(3):365–370. DOI: https://doi.org/10.1177/0310057X1404200314.</mixed-citation><mixed-citation xml:lang="ru">Ogurlu M., Sari S., Kucuk M., Bakis M., Uguir B.,Eshraghi Y.E. et al. Comparison of the effect of propofol and sevoflurane anaesthesia on acute and chronic postoperative pain after hysterectomy // Anaesth Intensive Care. 2014. Vol. 42. N 3. P. 365–370. DOI: https://doi.org/10.1177/0310057X1404200314.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Li M, Mei W, Wang P, Yu Y, Qian W, Zhang ZG et al. Propofol reduces early post-operative pain after gynecological laparoscopy. Acta Anaesthesiol Scand. 2012;56(3):368–375. DOI: https://doi.org/10.1111/j.1399-6576.2011.02603.x.</mixed-citation><mixed-citation xml:lang="ru">Li M., Mei W., Wang P, Yu Y., Qian W., Zhang Z.G. et al. Propofol reduces early post-operative pain after gynecological laparoscopy // Acta Anaesthesiol Scand. 2012. Vol. 56. N 3. P. 368–375. DOI: 10.1111/j.1399-6576.2011.02603.x.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Qiu Q, Choi S, Wong S, Irwin MG, Cheung CW Effects of intra-operative maintenance of general anaesthesia with propofol on postoperative pain outcomes: a systematic review and meta-analysis. Anaesthesia. 2016;71:1222–1233. DOI: https://doi.org/10.1111/anae.13578.</mixed-citation><mixed-citation xml:lang="ru">Qiu Q., Choi S., Wong S. Irwin M.G., Cheung C.W. Effects of intra-operative maintenance of general anaesthesia with propofol on postoperative pain outcomes: a systematic review and meta-analysis // Anaesthesia. 2016. Vol. 71. P. 1222–1233. DOI: https://doi.org/10.1111/anae.13578.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Peng K, Liu H-Y, Wu S-R, Liu H, Zhang Z-C, Ji F-H. Does propofol anesthesia lead to less postoperative pain compared with inhalational anesthesia? A systematic review and meta-analysis. Anesth Analg. 2016;123(4):846–858. DOI: https:// doi.org/10.1213/ANE.0000000000001504.</mixed-citation><mixed-citation xml:lang="ru">Peng K., Liu H-Y., Wu S-R., Liu H., Zhang Z-C., Ji F-H. Does propofol anesthesia lead to less postoperative pain compared with inhalational anesthesia? A systematic review and meta-analysis // Anesth Analg. 2016. Vol. 123. N 4. P. 846–858. DOI: https://doi.org/10.1213/ANE.0000000000001504.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Song J, Shin J, Lee E, Choi DK, Bang JY, Chin JHC et al. Incidence of post-thoracotomy pain: a comparison between total intravenous anaesthesia and inhalation anaesthesia. Eur J Cardiothorac Surg. 2012;41(5):1078–1082. DOI: https://doi.org/10.1093/ejcts/ezr133.</mixed-citation><mixed-citation xml:lang="ru">Song J., Shin J., Lee E., Choi D.K., Bang J.Y., Chin J.H.C. et al. Incidence of post-thoracotomy pain: a comparison between total intravenous anaesthesia and inhalation anaesthesia. Eur J. Cardiothorac Surg. 2012. Vol. 41. N 5. P. 1078–1082. DOI: https://doi.org/10.1093/ejcts/ezr133.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Zhang Y, Eger E, Dutton R, Sonner JM. Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration. Anesth Analg. 2000;91(2):462–466. DOI: https://doi.org/10.1097/00000539-200008000-00044.</mixed-citation><mixed-citation xml:lang="ru">Zhang Y., Eger E., Dutton R., Sonner J.M. Inhaled anesthetics have hyperalgesic effects at 0.1 minimum alveolar anesthetic concentration // Anesth Analg. 2000. Vol. 91. N 2. P. 462–466. DOI: https://doi.org/10.1097/00000539-200008000-00044.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Rowley T, Daniel D, Flood P. The role of adrenergic and cholinergic transmission in volatile anesthetic-induced pain enhancement. Anesth Analg. 2005;100(4):991–995. DOI: https://doi.org/10.1213/01.ane.0000147708.73945.b3.</mixed-citation><mixed-citation xml:lang="ru">Rowley T., Daniel D., Flood P. The role of adrenergic and cholinergic transmission in volatile anesthetic-induced pain enhancement // Anesth Analg. 2005. Vol. 100. N 4. P. 991–995. DOI: https://doi.org/10.1213/01.ane.0000147708.73945.b3.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">O’Connor T, Abram S. Inhibition of nociception-induced spinal sensitization by anesthetic agents. Anesthesiology. 1995;82:259–266. DOI: https://doi.org/10.1097/00000542-199501000-00031.</mixed-citation><mixed-citation xml:lang="ru">O’Connor T., Abram S. Inhibition of nociception-induced spinal sensitization by anesthetic agents. // Anesthesiology. 1995. Vol. 82. P. 259–266. DOI: https://doi.org/10.1097/00000542-199501000-00031.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Bandschapp O, Filitz J, Ihmsen H, Berset A, Urwyler A, Kop-pert W et al. Analgesic and antihyperalgesic properties of propofol in a human pain model. Anesthesiology. 2010;113:421–428. DOI: https://doi.org/10.1097/ALN.0b013e3181e33ac8.</mixed-citation><mixed-citation xml:lang="ru">Bandschapp O., Filitz J., Ihmsen H., Berset A., Urwyler A. Koppert W. et al. Analgesic and antihyperalgesic properties of propofol in a human pain model // Anesthesiology. 2010. Vol. 113. P. 421–428. DOI: https://doi.org/10.1097/ALN.0b013e3181e33ac8.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Chen R, Chen T, Chen T, Lin L-L,Chang C-C, Chang H-C et al. Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages. Ann N Y Acad Sci. 2005;1042: 262–271. DOI: https://doi.org/10.1196/annals.1338.030.</mixed-citation><mixed-citation xml:lang="ru">Chen R., Chen T., Chen T., Lin L.-L.,Chang C.-C., Chang H.-C. et al. Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages // Ann N Y Acad Sci. 2005. Vol. 1042. P. 262–271. DOI: https://doi.org/10.1196/annals.1338.030.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Zhao M, Joo D. Enhancement of spinal N-methyl-D-aspartate receptor function by remifentanil action at delta-opioid receptors as a mechanism for acute opioid-induced hyperalgesia or tolerance. Anesthesiology. 2008;109:308–317. DOI: https://doi.org/10.1097/ALN.0b013e31817f4c5d.</mixed-citation><mixed-citation xml:lang="ru">Zhao M., Joo D. Enhancement of spinal N-methyl-D-aspartate receptor function by remifentanil action at delta-opioid receptors as a mechanism for acute opioid-induced hyperalgesia or tolerance // Anesthesiology. 2008. Vol. 109 P. 308–317. DOI: https://doi.org/10.1097/ALN.0b013e31817f4c5d.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Kotani Y, Shimazawa M, Yoshimura S, Iwama T, Hara H. The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective properties. CNS Neurosci Ther. 2008;14:95–106. DOI: https://doi.org/10.1097/ALN.0b013e31817f4c5d.</mixed-citation><mixed-citation xml:lang="ru">Kotani Y., Shimazawa M., Yoshimura S., Iwama T., Hara H. The experimental and clinical pharmacology of propofol, an anesthetic agent with neuroprotective properties // CNS NeurosciTher. 2008. Vol. 14. P. 95–106. DOI: https://doi.org/10.1097/ALN.0b013e31817f4c5d.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Singler B, Troster A, Manering N, Schuttler J, Koppert W. Modulation of remifentanil-induced postinfusion hyperalgesia by propofol. Anesth Analg. 2007;104(6):1397–1403. DOI: https://doi.org/10.1213/01.ane.0000261305.22324.f3.</mixed-citation><mixed-citation xml:lang="ru">Singler B., Troster A., Manering N., Schuttler J., Koppert W. Modulation of remifentanil-induced postinfusion hyperalgesia by propofol // Anesth Analg. 2007. Vol. 104. N 6. P. 1397–1403. DOI:https://doi.org/10.1213/01.ane.0000261305.22324.f3.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Pandit J, Andrade J, Bogod D, Hitchman J, Jonker W, Lucas N et al. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors. Br J Anaesth. 2014;113:549–559. DOI: https://doi.org/10.1093/bja/aeu313.</mixed-citation><mixed-citation xml:lang="ru">Pandit J., Andrade J., Bogod D., Hitchman J., Jonker W., Lucas N. et al. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors // Br J Anaesth. 2014. Vol. 113. P. 549–559. DOI: https://doi.org/10.1093/bja/aeu313.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
