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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Regional Anesthesia and Acute Pain Management</journal-id><journal-title-group><journal-title xml:lang="en">Regional Anesthesia and Acute Pain Management</journal-title><trans-title-group xml:lang="ru"><trans-title>Регионарная анестезия и лечение острой боли</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1993-6508</issn><issn publication-format="electronic">2687-1394</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">42838</article-id><article-id pub-id-type="doi">10.17816/RA42838</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Intensive therapy systemic toxicity of local anesthetics (clinical guidelines)</article-title><trans-title-group xml:lang="ru"><trans-title>Интенсивная терапия при системной токсичности местными анестетиками (клинические рекомендации)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lakhin</surname><given-names>Roman E.</given-names></name><name xml:lang="ru"><surname>Лахин</surname><given-names>Роман Евгеньевич</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD, DSc., docent of department of anesthesiology and critical care medicine, Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, доцент кафедры анестезиологии и реаниматологии ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова» МО РФ</p></bio><email>doctor-lahin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Koryachkin</surname><given-names>V. A</given-names></name><name xml:lang="ru"><surname>Корячкин</surname><given-names>В. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Uvarov</surname><given-names>D. N</given-names></name><name xml:lang="ru"><surname>Уваров</surname><given-names>Д. Н</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ulrikh</surname><given-names>G. E</given-names></name><name xml:lang="ru"><surname>Ульрих</surname><given-names>Г. Э</given-names></name></name-alternatives><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shifman</surname><given-names>E. M</given-names></name><name xml:lang="ru"><surname>Шифман</surname><given-names>Е. М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gluschenko</surname><given-names>V. A</given-names></name><name xml:lang="ru"><surname>Глущенко</surname><given-names>В. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kulikov</surname><given-names>A. V</given-names></name><name xml:lang="ru"><surname>Куликов</surname><given-names>А. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff7"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Military Medical Academy named after S.M. Kirov of the Ministry of Defense of RF</institution></aff><aff><institution xml:lang="ru">ФГБВОУ ВПО «Военно-медицинская академия им. С.М. Кирова»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">R.R. Vreden Russian Research Institute of Traumatology and Orthopedics</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский научно-исследовательский институт травматологии и ортопедии им. Р.Р. Вредена»</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Northern State Medical University</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Северный государственный медицинский университет» МЗ РФ</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">St. Petersburg State Pediatric Medical University</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Санкт-Петербургский государственный педиатрический медицинский университет» МЗ РФ</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">M.F. Vladimirsky Moscow Regional Research Clinical Institute</institution></aff><aff><institution xml:lang="ru">ГБУЗ Московской области «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">First Saint-Petersburg State Medical University named after. I.P. Pavlov, MH of RF</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» МЗ РФ</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">Ural State Medical Academy, MH of RF</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Уральская государственная медицинская академия» МЗ РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-09-15" publication-format="electronic"><day>15</day><month>09</month><year>2016</year></pub-date><volume>10</volume><issue>3</issue><issue-title xml:lang="en">VOL 10, NO3 (2016)</issue-title><issue-title xml:lang="ru">ТОМ 10, №3 (2016)</issue-title><fpage>197</fpage><lpage>204</lpage><history><date date-type="received" iso-8601-date="2020-08-24"><day>24</day><month>08</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО "Эко-Вектор"</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2020-10-01"/></permissions><self-uri xlink:href="https://rjraap.com/1993-6508/article/view/42838">https://rjraap.com/1993-6508/article/view/42838</self-uri><abstract xml:lang="en"><p>Development of the systemic toxicity of local anesthetics can quickly lead to severe bradycardia and hypotension, up to cardiac arrest. The presented clinical recommendations designed to optimize medical care and are included in the list of mandatory clinical protocols according to the Helsinki Declaration on Patient Safety in Anaesthesiology. This review summarizes the main mechanisms of toxicity when using local anesthetics. The guidelines set out criteria and signs of systemic toxicity, recommendations for its prevention. The algorithm of action and recommended dosage of drugs. An intensive care protocol systemic toxicity of local anesthetics including the use of lipid emulsion.</p></abstract><trans-abstract xml:lang="ru"><p>Развитие системной токсичности местными анестетиками может быстро приводить к тяжелой брадикардии и гипотензии, вплоть до остановки кровообращения. Представленные клинические рекомендации разработаны с целью оптимизации медицинской помощи и включены в перечень обязательных клинических протоколов согласно Хельсинкской декларации по безопасности пациентов в анестезиологии. В предлагаемом обзоре обобщены основные механизмы возникновения токсических реакций при использовании местных анестетиков. В рекомендациях изложены критерии и признаки развития системной токсичности, даны рекомендации по ее профилактике. Описаны алгоритм действий и дозировки рекомендуемых препаратов. Приведен протокол интенсивной терапии системной токсичности местными анестетиками, включающий использование жировой эмульсии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>local anesthetics</kwd><kwd>systemic toxicity</kwd><kwd>regional anesthesia</kwd><kwd>intensive care</kwd><kwd>lipid emulsion</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>местные анестетики</kwd><kwd>системная токсичность</kwd><kwd>регионарная анестезия</kwd><kwd>интенсивная терапия</kwd><kwd>жировая эмульсия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Dillane D., Finucane B. T. Local Anesthetic systemic toxicity. 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