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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Regional Anesthesia and Acute Pain Management</journal-id><journal-title-group><journal-title xml:lang="en">Regional Anesthesia and Acute Pain Management</journal-title><trans-title-group xml:lang="ru"><trans-title>Регионарная анестезия и лечение острой боли</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1993-6508</issn><issn publication-format="electronic">2687-1394</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">36260</article-id><article-id pub-id-type="doi">10.17816/RA36260</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Planning clinical research. Question #2: Choosing of endpoints</article-title><trans-title-group xml:lang="ru"><trans-title>Планируем клиническое исследование. Вопрос 2: Выбор конечных точек</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tikhova</surname><given-names>Galina P.</given-names></name><name xml:lang="ru"><surname>Тихова</surname><given-names>Галина Петровна</given-names></name></name-alternatives><email>gala@critical.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">FSBI “Karelian Research Center of Russian Academy of Science"</institution></aff><aff><institution xml:lang="ru">Карельский научный центр РАН</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2014</year></pub-date><volume>8</volume><issue>4</issue><issue-title xml:lang="en">VOL 8, NO4 (2014)</issue-title><issue-title xml:lang="ru">ТОМ 8, №4 (2014)</issue-title><fpage>67</fpage><lpage>70</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО "Эко-Вектор"</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2020-10-01"/></permissions><self-uri xlink:href="https://rjraap.com/1993-6508/article/view/36260">https://rjraap.com/1993-6508/article/view/36260</self-uri><abstract xml:lang="en"><p>The paper is devoted to the questions of correct choosing of endpoints that correspond the goal of the study as well as estimating of potential inaccuracy and bias of sample data due to particularities of different kind of endpoints. The author presents endpoints classification and considers various techniques to solve the problems arising from the endpoint nature.</p></abstract><trans-abstract xml:lang="ru"><p>Статья посвящена вопросам правильного выбора конечных точек, соответствующих цели исследования и оценке потенциальной неточности и смещения выборочных данных, обусловленных особенностями этих конечных точек. Приводится классификация конечных точек и рассматриваются приемы решения проблем, вызванных их природой.</p></trans-abstract><kwd-group xml:lang="en"><kwd>protocol of clinical study</kwd><kwd>endpoint of clinical study</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>протокол клинического исследования</kwd><kwd>конечная точка исследования</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Adams-Huet B., Ahn C. Bridging clinical investigators and statisticians: writing the statistical methodology for a research proposal. J Investig Med. 2009; 57(8): 818-824.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Prentice R.L. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med. 1989; 8(4): 431-440.</mixed-citation></ref></ref-list></back></article>
