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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Regional Anesthesia and Acute Pain Management</journal-id><journal-title-group><journal-title xml:lang="en">Regional Anesthesia and Acute Pain Management</journal-title><trans-title-group xml:lang="ru"><trans-title>Регионарная анестезия и лечение острой боли</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1993-6508</issn><issn publication-format="electronic">2687-1394</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">36201</article-id><article-id pub-id-type="doi">10.17816/RA36201</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Chronic post-thoracotomy pain (literature review)</article-title><trans-title-group xml:lang="ru"><trans-title>Хронический болевой синдром после операций на грудной клетке</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Timerbayev</surname><given-names>V. Kh</given-names></name><name xml:lang="ru"><surname>Тимербаев</surname><given-names>В. Х</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lesnik</surname><given-names>V. Yu</given-names></name><name xml:lang="ru"><surname>Лесник</surname><given-names>В. Ю</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Genov</surname><given-names>P. G</given-names></name><name xml:lang="ru"><surname>Генов</surname><given-names>П. Г</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">FSBI “N.V. Sklifosovsky Research Institute of Emergency Care”, Moscow Healthcare Department, 129090, Moscow</institution></aff><aff><institution xml:lang="ru">ГБУЗ «НИИ скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы», 129090, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2014-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2014</year></pub-date><volume>8</volume><issue>1</issue><issue-title xml:lang="en">VOL 8, NO1 (2014)</issue-title><issue-title xml:lang="ru">ТОМ 8, №1 (2014)</issue-title><fpage>14</fpage><lpage>20</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, ООО "Эко-Вектор"</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2020-10-01"/></permissions><self-uri xlink:href="https://rjraap.com/1993-6508/article/view/36201">https://rjraap.com/1993-6508/article/view/36201</self-uri><abstract xml:lang="en"><p>The incidence of chronic post-thoracotomy pain may achieve up to 80% in patients undergone thoracic surgery. Many pathogenic factors are involved in developing of chronic pain and the main of them is injury of intercostal nerves. The neuropathic component of pain occurs in almost half of such patients worsening their status significantly and disrupting their activity. Valuable prophylaxis of chronic post- thoracotomy pain may be provided by preventive using methods of regional analgesia and epidural anesthesia and paravertebral block are the basic techniques for these purpose.</p></abstract><trans-abstract xml:lang="ru"><p>Частота формирования хронического постторакотомического болевого синдрома может достигать 80% у пациентов, перенесших операции на грудной клетке. В развитие хронической боли вовлечены множество патогенетических факторов, основным из которых является повреждение межреберных нервов. Нейропатический компонент боли присутствует почти у половины таких пациентов, существенно ухудшая их состояние и нарушая работоспособность. Существенную профилактику хронического постторакотомического болевого синдрома можно осуществить, превентивно применяя регионарные методы обезболивания, основными из которых являются продленные эпидуральная анестезия и паравертебральная блокада</p></trans-abstract><kwd-group xml:lang="en"><kwd>post-thoracotomy pain</kwd><kwd>thoracic surgery</kwd><kwd>epidural anesthesia</kwd><kwd>paravertebral block</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хронический постторакотомический болевой синдром</kwd><kwd>торакальная хирургия</kwd><kwd>нейропатическая боль</kwd><kwd>эпидуральная анестезия</kwd><kwd>паравертебральная блокада</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Merskey H., Bogduk H. Classification of chronic pain. In: Merskey H., Bogduk H., editors. Descriptions of chronic pain syndromes and definitions of pain terms. 2nd ed., Seattle: IASP Press. 1994: 143-144.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Blades B., Dugan D. War wounds of chest observed at the Thoracic Surgery Center, Walter Reed General Hospital. J. Thorac. Surg. 1944; 13: 294-306.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Kanner R. Diagnosis and management of neuropathic pain in patients with cancer. Cancer Invest. 2001; 19 (3): 324-333.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Pluijms W., Steegers M., Verhagen A., Scheffer G., Wilder-Smith O. Chronic post-thoracotomy pain: a retrospective study. Acta Anaesthesiol. Scand. 2006; 50 (7): 804-808.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Perttunen K., Tasmuth T., Kalso E. Chronic pain after thoracic surgery: a follow-up study. Acta Anaesthesiol. Scand. 1999; 43 (5): 563-567.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Wildgaard K., Iversen M., Kehlet H. Chronic Pain After Lung Transplantation. Clin. J. Pain. 2010; 26 (3): 217-222.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Steegers M., Snik D., Verhagen A., van der Drift M., Wilder-Smith O. Only half of the chronic pain after thoracic surgery shows a neuropathic component. J. Pain. 2008; 9 (10): 955-961.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Searle R., Simpson M., Simpson K., Milton R., Bennett M. Can chronic neuropathic pain following thoracic surgery be predicted during the postoperative period? Interact. Cardiovasc. Thorac. Surg. 2009; 9 (6): 999-1002.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Wallace A., Wallace M. Postmastectomy and postthoracotomy pain. Anesthesiol. Clin. North. Am. 1997; 15(2): 353-370.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>DiMarco A., Oca O., Renston J. Lung Herniation. A Cause of Chronic Chest Pain Following Thoracotomy. Chest. 1995; 107 (3): 877-879.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Dajczman E., Gordon A., Kreisman H., Wolkove N. Long-term postthoracotomy pain. Chest. 1991; 99 (2): 270-274.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Ochroch E., Gottschalk A., Augostides J., Carson K., Kent L., Malayaman N. et al. Long-term pain and activity during recovery from major thoracotomy using thoracic epidural analgesia. Anesthesiology. 2002; 97 (5): 1234-1244.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Maguire M., Ravenscroft A., Beggs D., Duffy J. A questionnaire study investigating the prevalence of the neuropathic component of chronic pain after thoracic surgery. Eur. J. Cardiothorac. Surg. 2006; 29 (5): 800-805.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>De Cosmo G., Congedo E., Lai C., Primieri P., Dottarelli A., Aceto P. Preoperative psychologic and demographic predictors of pain perception and tramadol consumption using intravenous patient-controlled analgesia. Clin. J. Pain. 2008; 24 (5): 399-405.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Ochroch E., Gottschalk A., Troxel A., Farrar J. Women suffer more short and long-term pain than men after major thoracotomy. Clin. J. Pain. 2006; 22 (5): 491-498.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Gotoda Y., Kambara N., Sakai T., Kishi Y., Kodama K., Koyama T. The morbidity, time course and predictive factors for persistent post-thoracotomy pain. Eur. J. Pain. 2001; 5 (1): 89-96.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Ip H., Abrishami A., Peng P., Wong J., Chung F. Predictors of postoperative pain and analgesic consumption: a qualitative systematic review. Anesthesiology. 2009; 111 (3): 657-677.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Ziyade S., Baskent A., Tanju S., Toker A., Dilege S. Isokinetic muscle strength after thoracotomy: Standard vs. muscle-sparing posterolateral thoracotomy. J. Thorac. Cardiovasc Surg. 2010; 58 (5): 295-298.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Macrae W. Chronic post-surgical pain: 10 years on. Br. J. Anaesth. 2008; 101 (1): 77-86.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Maguire M., Latter J., Mahajan R., Beggs F., Duffy J. A study exploring the role of intercostal nerve damage in chronic pain after thoracic surgery. Eur. J. Cardiothorac. Surg. 2006; 29 (6): 873-879.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Guastella V., Mick G., Soriano C., Vallet L., Escande G., Dubray С. et al. A prospective study of neuro pathic pain induced by thoracotomy: Incidence, clinical description and diagnosis. Pain. 2011; 152 (1): 74-81.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Landreneau R., Mack M., Hazelrigg S., Naunheim K., Dowling R., Ritter P. et al. Prevalence of chronic pain after pulmonary resection by thoracotomy or video-assisted thoracic surgery. J. Thorac. Cardiovasc. Surg. 1994; 107 (4): 1079-1085.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Rogers M., Henderson L., Mahajan R., Duffy J. Preliminary the neurophysiological assessment of intercostal nerve injury thoracotomy. Eur. J. Cardiothorac Surg. 2002; 21 (2): 298-301.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Miyazaki T., Sakai T., Tsuchiya T., Yamasaki N., Tagawa T., Mine M. et al. Assessment and follow-up of intercostal nerve damage after video-assisted thoracic surgery. Eur. J. Cardiothorac. Surg. 2011; 39 (6):1033-1039.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Benedetti F., Vighetti S., Ricco C., Amanzio M., Bergamasco L., Casadio C. et al. Neurophysiologic assessment of nerve impairment in posterolateral and muscle-sparing thoracotomy. J. Thorac. Cardiovasc. Surg. 1998; 115 (4): 841-847.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Maguire M., Latter J., Mahajan R., Beggs F., Duffy J. A study exploring the role of intercostal nerve damage in chronic pain after thoracic surgery. Eur. J. Cardiothorac. Surg. 2006; 29 (6): 873-879.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Wildgaard K., Ringsted T., Aasvang E., Ravn J., Werner M., Kehlet H. Neurophysiological characterization of persistent post-thoracotomy pain. Clin. J. Pain. 2012; 28 (2): 136-142.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Buvanendran A., Kroin J., Kerns J., Nagalla S., Tuman K. Characterization of a new animal model for evaluation of persistent postthoracotomy pain. Anesth. Analg. 2004; 99 (5): 1453-1460.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Landreneau R., Pigula F., Luketich J., Keenan R., Bartley S., Fetterman L. et al. Acute and chronic morbidity differences between muscle sparing and standard lateral thoracotomies. J. Thorac. Cardiovasc. Surg. 1996; 112 (5): 1346-1350.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Ochroch E., Gottschalk A., Augoustides J., Aukburg S., Kaiser L., Shrager J. Pain and physical function are similar following axillary, muscle-sparing vs posterolateral thoracotomy. Chest. 2005; 128 (4): 2664-2670.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Sabanathan S. Has postoperative pain been eradicated? Ann. R. Coll. Surg. Engl. 1995; 77 (3): 202-209.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Hansen J. Intercostal neuralgia following thoracoabdominal surgery. Acta. Chir. Scand. Suppl. 1973; 433: 180-182.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Cerfolio R., Price T., Bryant A., Sale Bass C., Bartolucci A. Intracostal sutures decrease the pain of thoracotomy. Ann. Thorac. Surg. 2003; 76 (2): 407-411.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Landreneau R., Hazelrigg S., Mack M., Dowling R., Burke D., Gavlick J. et al. Postoperative pain related morbidity: video-assisted thoracic surgery vs. thoracotomy. Ann. Thorac. Surg. 1993; 56 (6): 1285-1289.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Kirby T., Mack M., Landreneau R., Rice T. Lobectomy--video-assisted thoracic surgery versus muscle-sparing thoracotomy. A randomized trial. J. Thorac. Cardiovasc. Surg. 1995; 109 (5): 997-1001.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Furrer M., Rechsteiner R., Eigenmann V., Signer C., Althaus U., Ris H. Thoracotomy and thoracoscopy: postoperative pulmonary function, pain and chest wall complaints. Eur. J. Cardiothorac. Surg. 1997; 12 (1): 82-87.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Passlick B., Born C., Sienel W., Thetter O. Incidence of chronic pain after minimal-invasive surgery for spontaneous pneumothorax. Eur. J. Cardiothorac. Surg. 2001; 19 (3): 355-358.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Wildgaard K., Ringsted T., Hansen H., Petersen R., Werner M., Kehlet H. Quantitative sensory testing of persistent pain after video-assisted thoracic surgery lobectomy. Br. J. Anaesth. 2012; 108 (1): 126-133.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Milton R., Cale A. Chronic pain due to talc pleurodesis for spontaneous pneumothorax. Ann. Thorac. Surg. 2003; 76 (5): 1740-1741.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Katz J., Jackson M., Kavanagh B., Sandler A. Acute pain after thoracic surgery predicts long-term post-thoracotomy pain. Clin. J. Pain. 1996; 12 (1): 50-55.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Yegin A., Erdogan A., Kayacan N., Karsli B. Early postoperative pain management after thoracic surgery; pre- and postoperative versus postoperative epidural analgesia: a randomised study. Eur. J. Cardiothorac. Surg. 2003; 24 (3): 420-424.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Obata H., Saito S., Fujita N., Fuse Y., Ishizaki K., Goto F. Epidural block with mepivacaine before surgery reduces longterm post-thoracotomy pain. Can. J. Anaesth. 1999; 46 (12): 1127-1132.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Sentürk M., Ozcan P., Talu G., Kiyan E., Camci E., Ozyalçin S. et al. The effects of three different analgesia techniques on longterm postthoracotomy pain. Anesth. Analg. 2002; 94(1): 11-15.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Salengros J., Huybrechts I., Ducart A., Faraoni D., Marsala C., Barvais L. et al. Different anesthetic techniques associated with different incidences of chronic post-thoracotomy pain: low-dose remifentanil plus presurgical epidural analgesia is preferable to high-dose remifentanil with postsurgical epidural analgesia. J. Cardiothorac. Vasc. Anesth. 2010; 24 (4): 608-616.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Song J., Shin J., Lee E., Choi D., Bang J., Chin J. et al. Incidence of post-thoracotomy pain: a comparison between total intravenous anaesthesia and inhalation anaesthesia. Eur. J. Cardiothorac. Surg. 2012; 41 (5): 1078-1082.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Kairaluoma P., Bachmann M., Rosenberg P., Pere P. Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. Anesth. Analg. 2006; 103 (3): 703-708.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Lopes R., Lobo M., Cardoso G., Valente R., Sarmento C. Post thoracotomy chronic pain comparison of two locoregional techniques for postoperative analgesia: thoracic epidural and thoracic paravertebral block: 14AP3-4. Eur J. Anesth. 2012; 29 (Suppl. 50):198.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Finnerup N., Otto M., McQuay H., Jensen T., Sindrup S. Algorithm for neuropathic pain treatment: an evidence based proposal. Pain. 2005; 118 (3): 289-305.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Dualé C., Sibaud F., Guastella V., Vallet L., Gimbert Y., Taheri H. et al. Perioperative ketamine does not prevent chronic pain after thoracotomy. Eur. J. Pain. 2009; 13 (5): 497-505.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Ryu H., Lee C., Kim Y., Bahk J. Preemptive low-dose epidural ketamine for preventing chronic postthoracotomy pain: a prospective, double-blinded, randomized, clinical trial. Clin. J. Pain. 2011; 27 (4): 304-308.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Sano M., Inaba S., Yamamoto T., Nishino T. Intra-operative ketamine administration reduced the level of post-thoracotomy pain. Masui. 2005; 54 (1): 19-24.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Doyle E., Bowler G. Pre-emptive effect of multimodal analgesia in thoracic surgery. Br. J. Anaesth. 1998; 80 (2): 147-151.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Evans P. Cryoanalgesia. The application of low temperatures to nerves to produce anaesthesia or analgesia. Anaesthesia. 1981; 36 (11): 1003-1013.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Müller L., Salzer G., Ransmayr G., Neiss A. Intraoperative cryoanalgesia for postthoracotomy pain relief. Ann. Thorac. Surg. 1989; 48 (1): 15-18.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Bennett M., Attal N., Backonja M., Baron R., Bouhassira D., Freynhagen R. et al. Using screening tools to identify neuropathic pain. Pain. 2007; 127 (3): 199-203.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Matsutani N., Kawamura M. Significant improvement of chronic pain by Pregabalin after thoracotomy: report of four cases. Surg. Today. 2013; 43 (8): 915-917.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Sihoe A., Lee T., Wan I., Thung K., Yim A. The use of gabapentin for post-operative and post-traumatic pain in thoracic surgery patients. Eur. J. Cardiothorac. Surg. 2006; 29 (5): 795-799.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Solak O., Metin M., Esme H., Solak O., Yaman M., Pekcolaklar A. et al. Effectiveness of gabapentin in the treatment of chronic post-thoracotomy pain. Eur. J. Cardiothorac. Surg. 2007; 32 (1): 9-12.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Glantz L., Godovic G., Lekar M., Kramer M., Eidelman L. Efficacy of transdermal nitroglycerin combined with etodolac for the treatment of chronic post-thoracotomy pain: an open-label prospective clinical trial. J. Pain. Symptom. Manage. 2004; 27 (3): 277-281.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Ayad A., El Masry A. Epidural steroid and clonidine for chronic intractable post-thoracotomy pain: a pilot study. Pain. Pract. 2012; 12 (1): 7-13.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Fabregat G., Asensio-Samper J., Palmisani S., Villanueva-Pérez V., De Andrés J. Subcutaneous botulinum toxin for chronic post-thoracotomy pain.Pain. Pract. 2013; 13(3): 231-234.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Graybill J., Conermann T., Kabazie A., Chandy S. Spinal cord stimulation for treatment of pain in a patient with post thoracotomy pain syndrome. Pain Physician. 2011; 14 (5): 441445.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Koethe Y., Mannes A., Wood B. Image-guided Nerve Cryoablation for Post-thoracotomy Pain Syndrome.Cardiovasc. Intervent. Radiol. 2013; Aug 17 [Epub ahead of print].</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Theodosiadis P., Grosomanidis V., Samoladas E., Chalidis B. Subcutaneous targeted neuromodulation technique for the treatment of intractable chronic postthoracotomy pain. J. Clin. Anesth. 2010; 22 (8): 638-641.</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Thomas R. Challenges with current treatment of neuropathic pain. Eur. J. Pain. Suppl. 2010; 4 (2): 161-165.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Cohen S., Sireci A., Wu C., Larkin T., Williams K., Hurley R. Pulsed radiofrequency of the dorsal root ganglia is superior to pharmacotherapy or pulsed radiofrequency of the intercostal nerves in the treatment of chronic post-surgical thoracic pain. Pain. Physician. 2006; 9 (3): 227-236.</mixed-citation></ref></ref-list></back></article>
