<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Regional Anesthesia and Acute Pain Management</journal-id><journal-title-group><journal-title xml:lang="en">Regional Anesthesia and Acute Pain Management</journal-title><trans-title-group xml:lang="ru"><trans-title>Регионарная анестезия и лечение острой боли</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1993-6508</issn><issn publication-format="electronic">2687-1394</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">36190</article-id><article-id pub-id-type="doi">10.17816/RA36190</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Carl Roller, cocain, and local anesthesia Some less known and forgotten facts</article-title><trans-title-group xml:lang="ru"><trans-title>Карл Коллер, кокаин и местная анестезия. Некоторые малоизвестные и забытые факты</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Goerig</surname><given-names>M.</given-names></name><name xml:lang="ru"><surname>Гёриг</surname><given-names>Михаель</given-names></name></name-alternatives><bio xml:lang="en"><p>Department of Anaesthesia and Intensive Care</p></bio><bio xml:lang="ru"><p>Отделение анестезии и интенсивной терапии</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bacon</surname><given-names>D.</given-names></name><name xml:lang="ru"><surname>Бейкон</surname><given-names>Дуглас</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Van Zundert</surname><given-names>A.</given-names></name><name xml:lang="ru"><surname>Ван Цундерт</surname><given-names>Андре</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">University Hospital Hamburg</institution></aff><aff><institution xml:lang="ru">Университетская больница Гамбурга</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">School of Medicine, Wayne State University</institution></aff><aff><institution xml:lang="ru">Медицинская школа, Государственный университет Уэйна</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Catharina Hospital - Brabant Medical School</institution></aff><aff><institution xml:lang="ru">Больница Катарины, Брабантская медицинская школа</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">University of Ghent</institution></aff><aff><institution xml:lang="ru">Университет Гента</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">University of Maastricht</institution></aff><aff><institution xml:lang="ru">Университет Маастрихта</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2013</year></pub-date><volume>7</volume><issue>1</issue><issue-title xml:lang="en">VOL VII, NO1 (2013)</issue-title><issue-title xml:lang="ru">ТОМ 7, №1 (2013)</issue-title><fpage>54</fpage><lpage>62</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, ООО "Эко-Вектор"</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2020-10-01"/></permissions><self-uri xlink:href="https://rjraap.com/1993-6508/article/view/36190">https://rjraap.com/1993-6508/article/view/36190</self-uri><abstract xml:lang="en"><p>Modern-day local anesthesia began in 1884 with a discovery by young unknown ophthalmologist from Vienna named Carl Koller (1857 - 1944), who placed a cocaine solution on the cornea, thus producing insensibility. The news of his discovery spread throughout the world in less than a month. The story surrounding the revelation of the local anesthetic effect of cocaine and personalities involved is fascinating and relatively unknown.</p></abstract><trans-abstract xml:lang="ru"><p>Исходной точкой развития современных методов местной анестезии стало открытие анестетического действия кокаина на роговицу глаза, совершенное в 1884 году офтальмологом Карлом Коллером (1857 - 1944). Это открытие распахнуло дверь в новую эру успешной борьбы с операционной болью не только в офтальмологической хирургии, но в общехирургической практике в целом5. Событиям, предшествовавшим 1884 году, а также их героям и непосредственные участникам, которые на сегодняшний день остаются, к сожалению, малоизвестными, и посвящена данная статья.</p></trans-abstract><kwd-group xml:lang="en"><kwd>cocaine</kwd><kwd>ophthalmological surgery</kwd><kwd>history of anesthesia</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>кокаин</kwd><kwd>офтальмологическая хирургия</kwd><kwd>история анестезии</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kronfeld A. Professor Dr. Gustav Gaertner. Wien Med Wochenschr. 1937; 87: 1237.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Gaertner G. Ueber einen Apparat zur optischen Kontrolle des Pulses wahrend der Narkose. Zentralbl Chir. 1903; 36: 21-23.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Gaertner G. Uber einen Apparat zur Kontrolle des Pulses in der Narkose. Munch Med Wochenschr. 1903; 50: 1017-1018.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Neuburger M. Joseph Brettauer. Ein Gedenkblatt. Wien med Wochenschr. 1936; 10: 281-282.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Calatayud J., Gonzales A. History of the development and revolution of local anesthesia since the coca leaf. Anesthesiology. 2003; 98: 1503-1508.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Holmstedt B. Syndry episodes in the history of coca and cocaine. J Ethonography. 1981; 3: 118-147.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Willstatter R. Ueber die Constitution der Spaltungsproducte von Atropin und Cocarn. Ber Dtsch Chem Ges. 1898; 31: 1534-1553.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Willstatter R, Wolfes D, Mader H. Synthese des natiirlichen Cocains. Justus Liebigs Ann Chem. 1923; 34: 111-139.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Von Anrep N.B. Ueber die physiologischen wirkungen des Cocains. Pfliiger's Arch Ges Physiol. 1880; 21: 38-77.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Yentis S.M, Vlassow K.V. Vassily von Anrep, forgotten pioneer of regional anesthesia. Anesthesiology. 1999; 90: 890-895.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Aschenbrandt Th Die physiologische Wirkung und die Bedeutung des Cocain. Muriat. auf den menschlichen Organismus. Dtsch Med Wochenschr. 1883; 50: 730-732.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Freud S. Selbstdarstellung. Die Medizin der Gegenwart in Selbstdarstellungen. Vol. 4. Leipzig, Germany: L R Grote; 1925: 1-52.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Freud S. Letters of Sigmund Freud. New York, NY: Basic Books, Inc; 1960.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Wyklicky H., Skopec M. Carl Koller and his time in Vienna. Regional anaesthesia. In: Scott D.B, McClure J, Wildsmith J.A.W, eds. Regional Anaesthesia 1884-1984. Sweden: ICM AB: 1984: 12-17.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Holubar K. Salomon Strieker (1834-1898). Pioneer experimental pathologist. Am J Dermatopathol. 1987; 9: 149150.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Altman A. J., Albert D. M., Fournier G. A. Cocaine's use in ophthalmology: our 100-year heritage. Sun. Ophthalmol. 1985; 29: 300-306.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Arlt F. Meine Erlebnisse. Wiesbaden, Germany: Verlag von J.F. Bergmann; 1887.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Koller C. Historical notes on the beginning of local anesthesia. JAMA. 1928; 90: 1742-1743.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Freud S. Ueber Coca. Zentralblatt Ges Ther. 1884: 2: 289-314.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Breuer J. Die Selbststeuerung der Athmung durch den nervus vagus. In: Sitzungsbericht der kaiserlichen Akademie der Wissenschaften. Mathematisch-naturwissenschaftliche Classe. Wien, Austria: Abteilung; 1868: 58: 909-937.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Gaertner G. Die Entdeckung der Lokalanasthesie. Wien, Austria: Der neue Tag; 1919: 6.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Gaertner G. Ueber einen neuen Blutdruckmesser [Tonometer], Wien Med Wochenschr. 1899; 49: 1412-1418.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Honegger H, Hessler H. Die Entdeckung der Lokalanasthesie. Klin Monbl Augenheilkd Augenarztl Fortbild. 1970; 157: 428At38; 569-578, 714-723.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Hirsch C. Funfzig Jahre Lokal-Anasthesie. Wien Med Wochenschr. 1934; 44: 1177-1179.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Hirsch C. Die Stellung des Kokains in der Lokalanaesthesie einst und jetzt. Der Schmerz. 1928; 1: 105-113.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Koller C. Ueber die Verwendung des Cocain zur Anasthesierung am Auge. Wien Med Wochenschr. 1884; 43: 1276-1277; 44: 1310-1311.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Goldberg M. F. Cocaine: the first local anaesthetic and the third scourge of humanity. Ophthalmology. 1984; 102: 14431147.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Koller C. Historische Notiz iiber die ersten Anfange der Lokalanasthesie. Wien Med Wochenschr. 1928; 78: 601-602.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Noyes H. D. The Ophthalmological Congress in Heidelberg. Medical Record. 1884; 26: 417-418.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Holzmair E. Medicina in Nummis. Katalog der Sammlung Dr. Josef Brettauer. Unveranderter Nachdruck des (Catalogs mit einem Vorwort von Robert Gobi. Veroffentlichungen der Numismatischen Kommission. Band 22. Wien, Austria: Verlag der Osterreichischen Akademie der Wissenschaften; 1989.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Becker-Koller H.K. Carl Koller and cocain. Psycjoanal Quart. 1963, 32: 309-373.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Meller J. Gedenkworte zum 50. Jahrestages des Vortrages von Dr. Karl Koller iiber das Kokain vor der Gesellschaft der Aerzte in Wien. Wienklin Wochenschr. 1934; 44: 1313-1317.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Lesky E. Die Wiener Medizinische Schule im 19. Jahrhimdert. Graz-Koln: Verlag Hermann Bohlhaus, Nachfolger; 1965.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Liljestrand G. Carl Koller and the development of local anesthesia. Acta Physiol Scand. 1967; (suppl 299): 3-30.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Konigstein L. Uber das Cocainum muriaticum in seiner Anwendung in der Okulistic. Wien Med Presse. 1885; 25: 13401342; 26: 1355-1368.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Whitrow M. Freud and Wagner-Jauregg: a historiographical study. Psychiatric Bull. 1990: 14: 356-358.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Schonbauer L., Jantsch M. Lebenserinnerungen von Julius Wagner-Jauregg. Wien, Austria: Springer Verlag; 1950.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Wagner-Jauregg J. Zur Behandlung der progressiven Paralyse und Tabes. Wien Klin Wochenschr. 1921; 25: 1105-1109.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Notnagel M, Rossbach J. Handbuch der Arzneimittellehre. Berlin, Germany: Verlag von August Hirschwald; 1880.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Rossbach J. Cocain als ortliches Anaestheticum. Prioritatsreclamation. Berlin Klin Wochenschr. 1884; 50: 802.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Koller C. Cocain als ortliches Anaestheticum. Berlin Klin Wochenschr. 1885; 1: 2.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Koller C. Personal reminiscences of the first use of cocaine as a local anesthetic in eye surgery. Anesth Analg. 1928; 7: 9-11.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Fabritius A. Die Einfiihrung der Kokainanasthesie in die Ophthalmologic durch Dr. Carl Koller vor 50 Jahren. Klin Monbl Augenheilkd Augenarztl Fortbild. 1934; 10: 203-206.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Seidel G. Arzte ohne Nobelpreis, deren Entdeckungen Millionen Menschen geholfen haben. Geneva, Switzerland: Ariston Verlag. 1974; 24-32.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Pillat A. Dr. Karl Koller zum 100. Geburtstag. Wien Klin Wochenschr. 1958; 70: 381.</mixed-citation></ref></ref-list></back></article>
