Regional Anesthesia and Acute Pain ManagementRegional Anesthesia and Acute Pain ManagementРегионарная анестезия и лечение острой боли1993-65082687-1394Eco-Vector3614110.17816/RA36141ArticlesСтатьиResearch ArticlePotentially toxic concentrations in blood of total ropivacaine after bilateral transversus abdominis plane blocks; a pharmacokinetic studyПотенциально токсические общие концентрации ропивакаина в крови после билатеральных поперечных абдоминальных плоскостных блоков. Фармакокинетическое исследованиеTorupHenrikТорупХ.

Department of Anaesthesiology

Отделение анестезиологии

MitchellAnja U.МитчелА. У.

Department of Anaesthesiology

Отделение анестезиологии

BreindahlTorbenБрейндалТ.

Department of Anaesthesiology

Отделение анестезиологии

HansenEgon G.ХансенЭ. Г.

Department of Anaesthesiology

Отделение анестезиологии

RosenbergJacobРозенбергЯ.

Department of Anaesthesiology

Отделение анестезиологии

MøllerAnn M.МёллерА. М.

Department of Anaesthesiology

Отделение анестезиологии

Herlev HospitalБольница Герлев1506201262VOL 6, NO2 (2012)ТОМ 6, №2 (2012)374221072020Copyright ©; 2012, Eco-VectorCopyright ©; 2012, ООО "Эко-Вектор"2012Eco-VectorООО "Эко-Вектор"https://rjraap.com/1993-6508/article/view/36141

Elevated blood levels of lidocaine and ropivacaine have been described after transversus abdominis plane (TAP) block. Objective was to investigate the pharmacokinetic profile of ropivacaine after bilateral TAP blocks. Twenty-one adult patients presenting for abdominopelvic surgery with bilateral TAP blocks were enrolled. Ultrasound-guided TAP blocks with bilateral injections of 20ml ropivacaine 0.5 % w/v (total dose 200mg) were performed. Blood was sampled at 0, 10, 30 and 60min after TAP blocks.Total and free peak blood concentrations (Cmax) of Ropivacaine were measured. TAP blocks with bilateral injections of 20ml ropivacaine 0.5 % w/v gave rise to potentially toxic peak blood concentrations of total ropivacaine in one-third of the patients.

Описаны повышенные уровни лидокаина и ропивакаина после поперечного абдоминального плоскостного блока (ТАР-блока). Цель исследования состояла в изучении фармакокинетического профиля ропивакаина после билатеральных ТАР-блоков. В исследование был включен 21 взрослый пациент, которым планировалось выполнение ТАР-блока перед абдоминальной или гинекологической операцией. Билатерально в поперечное пространство живота между внутренней косой и поперечной мышцами под ультразвуковым контролем вводили по 20 мл 0,5 % раствора ропивакаина. Пробы крови забирались перед введением ропивакаина и затем через 10, 30 и 60 мин. Полученные результаты показали, что ТАР-блоки посредством билатеральных инъекций по 20 мл 0,5 % раствора ропивакаина обуславливают рост к потенциально токсичным уровням общего ропивакаина в крови у трети пациентов.

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