Regional Anesthesia and Acute Pain ManagementRegional Anesthesia and Acute Pain ManagementРегионарная анестезия и лечение острой боли1993-65082687-1394Eco-Vector3612310.17816/RA36123ArticlesСтатьиResearch ArticleSmoking as a risk factor of intraoperative nausea and vomiting in parturients undergone cesarean section under spinal anesthesiaКурение как фактор риска интраоперационной тошноты и рвоты при операции кесарева сечения в условиях спинномозговой анестезииPogodinA. M.ПогодинА. М.ShifmanE. M.ШифманЕ. М.

Faculty of refresher trainingfor health care professionals, Department of anesthesiology and resuscitation

Maternity Hospital “SeverStal", CherepovetsРодильный дом «Северсталь»People’s Friendship University of RussiaРУДН1503201261VOL 6, NO1 (2012)ТОМ 6, №1 (2012)111421072020Copyright ©; 2012, Eco-VectorCopyright ©; 2012, ООО "Эко-Вектор"2012Eco-VectorООО "Эко-Вектор"https://rjraap.com/1993-6508/article/view/36123

The goal of retrospective clinical study was to search and evaluate association between smoking and intraoperative nausea and vomiting (IONV) in parturients undergone cesarean section (CS) under spinal anesthesia (SA). One hundred thirty five women were enrolled. The group of smokers includes 21 patients while the group of non-smokers - 114 patients. Demographic and obstetric data has no statistically significant difference between the groups. IONV episodes occurred in 22 cases in both groups totally. Relative risk of IONV in smoking group was equaled 1,21 95%CI 0,45 to 3,21. This result suggests that there is no statistically and clinically significant difference in IONV incidence between smoking and non-smoking groups.

Представлены данные ретроспективного исследования связи курения с возникновением интраоперационной тошноты и рвоты (ИОТР) у 135 женщин. Группа курящих женщин в выборке составила 21, группа некурящих - 114 случаев. При схожих антропометрических и акушерских характеристиках пациенток отмечено 22 эпизода ИОТР. Относительный риск ИОТР в группе курящих составил 1,21 (0,45; 3,21), что свидетельствует об отсутствии статистически значимого различия между группами по показателю ИОТР.

smokingintraoperative nausea and vomitingинтраоперационная тошнота и рвотакурениеBalki M., Carvalho J.C.A. Intraoperative nausea and vomiting during cesarean section under regional anesthesia // Int.J. Obstet. Anest. 2005 Jul; 14 (3): 230-241.Погодин А.М., Шифман Е.М. Профилактика тошноты и рвоты при спинномозговой анестезии во время операции кесарева сечения // Регионарная анестезия и лечение острой боли. 2009; III(1): 11-14.Заболотских И.Б. Послеоперационная тошнота и рвота: механизмы, факторы риска, прогноз и профилактика. М.: Практическая медицина, 2009. 16-17.Apfel C.C., Roewer N. Risk factors for nausea and vomiting after general anesthesia: fictions and facts // Der Anaesthesist. 2000; 49(7): 629-642.Апфель К. Послеоперационная тошнота и рвота: мифы, факты, теория и реальность (перевод Е.Л. Непорада) по данным сайта http://sibanest.org/Глумчер Ф.С. Осложнения раннего послеоперационного периода // Острые и неотложные состояния в практике врача. 2008; 12(4): 15-19.Sweeney B.P., Grayling M. Smoking and anaesthesia: the pharmacological implications // Anaesthesia 2009; 64: 179-186.Chimbira W., Sweeney B.P. The effect of smoking on postoperative nausea and vomiting // Anaesthesia. 2000; 55: 540-543.Sweeney B.P. Why are smokers protected against PONV? // British Journal Anaesthesia. 2002; 89: 1-4.Wang J.S., Backman J.T., Taavitsainen P. Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans // Drug Metabolism and Disposition. 2000; 28: 959-965.Powell R.J., Thiercelin F.F., Vozeh S., Riegelman S. The Influence of cigarette smoking and sex on theophylline disposition // American Review of Respiratory Disease. 1977; 116: 17-23.Wolf C.R., Mahmood A., Henderson C.J. et al. Modulation of the cytochrome P450 system as a mechanism of chemoprotection // International Agency for Research on Cancer Scientific Publications. 1996; 139: 165-173.Conney A.H. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons // Cancer Research. 1982; 42: 4875-4917.Park B.K., Breckenridge A.M. Clinical implications of enzyme induction and enzyme inhibition // Clinical Pharmacokinetics. 1981; 6: 1-24.Lee B.I., Benowitz N.L., Jacob P. Cigarette abstinence, nicotine gum and theophylline disposition // Annals of Internal Medicine. 1987; 106: 553-559.Santos J.L., Calabranes J.A., Almoquera I. et al. Clinical implications of determination of plasma haloperidol levels // Acta Psychiatrica Scandinavica. 1989; 79: 348-354.Kalow B.K., Tank B.K. Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities. Clinical Pharmacology and Therapeutics // 1992; 50: 508-519.Zevin S., Benowitz N.L. Drug interactions with tobacco smoking // Clinical Pharmacokinetics. 1999; 36: 425-438.Biedler A., Wermelt J., Kunitz O. et al. A risk adapted approach reduces the overall institutional incidence of postoperative nausea and vomiting // Can.J. Anaesth. 2004; 51(1): 13-19.Cohen M.M., Duncan P G., De Boer D.P. et al. The postoperative interview: assessing risk factors for nausea and vomiting // Anesth. Analg. 1994; 78: 7-16.Hagemann E., Halvorsen A., Holgerson O. et al. Intramuscular ephedrine reduces emesis during the first three hours after abdominal hysterectomy // Acta Anaesthesiolog. Scand. 2000; 44: 107-111.Borgeat A., Ekatodramis G., Schenker C.A. Postoperative nausea and vomitingin regional anesthesia // Anesthesiology. 2003; 98: 530-547.Шифман Е.М. Преэклампсия, эклампсия, HELLP-синдром. Петрозаводск: Издательство «ИнтелТек», 2002. 432.Jokinen M.J., Olkolla K.T., Ahonen J., Neuvonen P.J. Effect of rifampicin and tobacco smoking on the pharmacokinetics of ropivicaine // Clinical Pharmacology and Therapeutics. 2001; 70: 344-350.