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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Regional Anesthesia and Acute Pain Management</journal-id><journal-title-group><journal-title xml:lang="en">Regional Anesthesia and Acute Pain Management</journal-title><trans-title-group xml:lang="ru"><trans-title>Регионарная анестезия и лечение острой боли</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1993-6508</issn><issn publication-format="electronic">2687-1394</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">108300</article-id><article-id pub-id-type="doi">10.17816/RA108300</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Current understanding of complex regional pain syndrome</article-title><trans-title-group xml:lang="ru"><trans-title>Современные представления о комплексном регионарном болевом синдроме</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3246-7452</contrib-id><name-alternatives><name xml:lang="en"><surname>Petrushin</surname><given-names>Alexander L.</given-names></name><name xml:lang="ru"><surname>Петрушин</surname><given-names>Александр Леонидович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>petrushin.59@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2386-9281</contrib-id><contrib-id contrib-id-type="spin">8850-2071</contrib-id><name-alternatives><name xml:lang="en"><surname>Antipin</surname><given-names>Eduard E.</given-names></name><name xml:lang="ru"><surname>Антипин</surname><given-names>Эдуард Эдуардович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), associate professor</p></bio><bio xml:lang="ru"><p>д.м.н., доцент</p></bio><email>vard67@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0900-4572</contrib-id><contrib-id contrib-id-type="spin">5490-9821</contrib-id><name-alternatives><name xml:lang="en"><surname>Bragina</surname><given-names>Svetlana V.</given-names></name><name xml:lang="ru"><surname>Брагина</surname><given-names>Светлана Валентиновна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.), associate professor</p></bio><bio xml:lang="ru"><p>к.м.н., доцент</p></bio><email>svetabragina69@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1267-9781</contrib-id><contrib-id contrib-id-type="spin">2074-3953</contrib-id><name-alternatives><name xml:lang="en"><surname>Yakovenko</surname><given-names>Maxim P.</given-names></name><name xml:lang="ru"><surname>Яковенко</surname><given-names>Максим Петрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>graduate student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>alter83@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1912-4252</contrib-id><name-alternatives><name xml:lang="en"><surname>Bochkareva</surname><given-names>Nadegda A.</given-names></name><name xml:lang="ru"><surname>Бочкарева</surname><given-names>Надежда Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>graduate student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>noirsept@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5768-3859</contrib-id><name-alternatives><name xml:lang="en"><surname>Koroleva</surname><given-names>Natalia I.</given-names></name><name xml:lang="ru"><surname>Королева</surname><given-names>Наталья Ивановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>graduate student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>la-reine-soleil@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Karpogory central district hospital</institution></aff><aff><institution xml:lang="ru">Карпогорская центральная республиканская больница</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Northern State Medical University</institution></aff><aff><institution xml:lang="ru">Северный государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-07-20" publication-format="electronic"><day>20</day><month>07</month><year>2022</year></pub-date><volume>16</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>5</fpage><lpage>21</lpage><history><date date-type="received" iso-8601-date="2022-05-28"><day>28</day><month>05</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Petrushin A.L., Antipin E.E., Bragina S.V., Yakovenko M.P., Bochkareva N.A., Koroleva N.I.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, Петрушин А.Л., Антипин Э.Э., Брагина С.В., Яковенко М.П., Бочкарева Н.А., Королева Н.И.</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Petrushin A.L., Antipin E.E., Bragina S.V., Yakovenko M.P., Bochkareva N.A., Koroleva N.I.</copyright-holder><copyright-holder xml:lang="ru">Петрушин А.Л., Антипин Э.Э., Брагина С.В., Яковенко М.П., Бочкарева Н.А., Королева Н.И.</copyright-holder><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjraap.com/1993-6508/article/view/108300">https://rjraap.com/1993-6508/article/view/108300</self-uri><abstract xml:lang="en"><p>Complex regional pain syndrome (CRPS) is a multifactorial pathology characterized by chronic pain, autonomic disorders, and motor dysfunction. This review discusses the mechanisms of CRPS development, as well as methods of its diagnosis, treatment, and prevention. In addition to drug treatment and physical therapy, issues of interventional methods for the treatment of CRPS are also covered. Along with sympathetic blocks and various ablation techniques under ultrasound and fluoroscopic guidance, a new waveform for spinal cord stimulation and new stimulation targets such as dorsal root ganglia have been proposed.</p></abstract><trans-abstract xml:lang="ru"><p>Комплексный регионарный болевой синдром (КРБС) – многофакторная патология, характеризующаяся хронической болью, вегетативными нарушениями и двигательной дисфункцией. В данном обзоре рассматриваются механизмы развития КРБС, а также методы диагностики, лечения и профилактики. Кроме медикаментозного лечения и физической терапии освещены также вопросы интервенционных методик лечения КРБС. Наряду с симпатическими блокадами и различными методами абляции под ультразвуковым и флюороскопическим контролем предложены новая форма волны для нейростимуляции спинного мозга и новые цели стимуляции, такие как ганглии задних корешков спинного мозга.</p></trans-abstract><kwd-group xml:lang="en"><kwd>complex regional pain syndrome</kwd><kwd>reflex sympathetic dystrophysyndrome</kwd><kwd>interventional pain management</kwd><kwd>cryoanalgesia</kwd><kwd>spinal cord stimulation</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>комплексный регионарный болевой синдром</kwd><kwd>рефлекторная симпатическая дистрофия</kwd><kwd>интервенционные методы лечения боли</kwd><kwd>криоанальгезия</kwd><kwd>нейростимуляция спинного мозга</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Paré A. Of the cure of wounds of the nervous system. In: The collected works of Ambroise Pare. 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