Nanosized platform based on magnetic nanoparticles for photodynamic therapy in oncology

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Resumo

Hybrid nanosystems based on iron oxide nanoparticles (IONPs) and human serum albumin (HSA) have been synthesized. Size and composition of HSA@IONPs nanosystems were characterized using UV/visible spectrophotometry (particularly, using the Bradford protein assay), dynamic light scattering and electron magnetic resonance. Methylene blue, as a model photosensitizer, was non-covalently bound to the nanosystems (5.8 μg per 1 mg of IONPs). The nanosystems were subjected to phototoxicity studies to confirm their suitability for photodynamic therapy, and the survival of cultured human breast adenocarcinoma MCF-7 tumor cells was analyzed. An increase in photoinduced cytotoxicity was observed when the photosensitizer was accumulated by cells upon delivery by the nanosystems, compared with a free photosensitizer at equivalent concentrations. HSA@IONPs are discussed as a promising platform for targeted delivery of a photosensitizer to tumor cells.

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Sobre autores

A. Bychkova

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Autor responsável pela correspondência
Email: anna.v.bychkova@gmail.com
Rússia, Moscow

A. Markova

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Rússia, Moscow

M. Nguyen

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Rússia, Moscow

M. Gradova

Semenov Federal Research Center for Chemical Physics of the Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Rússia, Moscow

M. Gorobets

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Rússia, Moscow

M. Motyakin

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Rússia, Moscow

M. Abdullina

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Rússia, Moscow

A. Toroptseva

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Rússia, Moscow

V. Kuzmin

Emanuel Institute of Biochemical Physics Russian Academy of Sciences

Email: anna.v.bychkova@gmail.com
Rússia, Moscow

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2. Fig. 1. Number of publications in the PubMed database by year, by the keyword “nanoparticles” and additional keywords indicated in the figure: “serum albumin”, “iron oxide”, “iron oxides”, “magnetite”.

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3. Fig. 2. Schematic representation of the stages of preparation of samples of hybrid nanosystems MS–(HSA@NCHO): obtaining nanoparticles in an albumin coating and non-covalent binding of nanoparticles to methylene blue.

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4. Fig. 3. Absorption spectra of methylene blue in water (1) and in the supernatant solution after magnetic separation of MS–(HSA@NCHO) (2).

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5. Fig. 4. Volume distributions of particle sizes obtained by dynamic light scattering in the control sample of NChOZh (left) and the experimental sample of ChSA@NChOZh (right).

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6. Fig. 5. Dark (1) and photoinduced cytotoxicity (2) of HSA@NCHO, MS–(HSA@NCHO) and MS on MCF-7 cells.

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