Synthesis, Structure and Biological Activity of Cu(II), Ni(II), Co(II) Complexes with N-[2-[(E)-2-furylmethylaminomethyl)phenyl]-4-methyl-benzenesulfamide

A. A. Shiryaeva; Ширяева А. А.; V. G. Vlasenko; Власенко В. Г.; A. S. Burlov; Бурлов А. С.; Yu. V. Koshienko; Кощиенко Ю. В.; B. V. Chaltsev; Чальцев Б. В.; V. A. Lazarenko; Лазаренко В. А.; N. I. Makarova; Макарова Н. И.; A. V. Metelitsa; Метелица А. В.; A. A. Zubenko; Зубенко А. А.; S. A. Mashchenko; Мащенко С. А.

doi:10.31857/S0132344X25060053

Synthesis, Structure and Biological Activity of Cu(II), Ni(II), Co(II) Complexes with N-[2-[(E)-2-furylmethylaminomethyl)phenyl]-4-methyl-benzenesulfamide

Authors: Shiryaeva A.A.¹, Vlasenko V.G.¹, Burlov A.S.², Koshienko Y.V.², Chaltsev B.V.², Lazarenko V.A.³, Makarova N.I.², Metelitsa A.V.², Zubenko A.A.⁴, Mashchenko S.A.²
Affiliations:
1. Institute of Physics, Southern Federal University
2. Institute of Physical and Organic Chemistry, Southern Federal University
3. National Research Center “Kurchatov Institute”
4. North Caucasian Zonal Research Veterinary Institute
Issue: Vol 51, No 6 (2025)
Pages: 400-410
Section: Articles
URL: https://rjraap.com/0132-344X/article/view/687271
DOI: https://doi.org/10.31857/S0132344X25060053
EDN: https://elibrary.ru/KISLQY
ID: 687271

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Abstract

Synthesized N-[2-[(E)-2-furylmethyliminomethyl)phenyl]-4-methyl-benzenesulfamide (HL) and complexes of Cu(II), Ni(II), Co(II) based on its ML₂ composition. The composition, structure, and spectral properties of the obtained compounds were studied using elemental analysis, ¹H NMR (for HL), IR spectroscopy, and electron absorption spectroscopy. The crystal structure of Cu(II), Ni(II), and Co(II) complexes was determined by X-ray diffraction (CCDC No. 2420740, 2420738, and 2420739, respectively). It is shown that two deprotonated ligands are chelated coordinated to metal ions by nitrogen atoms of the tosylamine and azomethine fragments of the ligand. The geometry of the surroundings of copper(II), nickel(II), and cobalt(II) ions corresponds to a strongly distorted tetrahedron. The electronic absorption spectra of HL and metal complexes have been studied. Azomethine HL and metal complexes were studied for antibacterial, protistocidal, and fungistatic activities. It was found that all compounds did not have fungistatic activity against Penicillium italicum, antibacterial activity against Staphylococcus aureus and Escherichia coli, and only for HL showed procystoid activity against Colpoda steinii at the level of the reference drug chloroquine.

Keywords

azomethine, metallochelates, 2-(N-tosylamino)benzaldehyde, IR, ¹H NMR, UV-spectroscopy, X-ray diffraction analysis

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